Development of new synthetic methodologies for indole derivatives

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2010

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Kılıklı, Ahmet Alper

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Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besides this, another objective is to observe and discuss effects of two different substituents on the homophtalic acid system through the synthetic route. Initially starting from homophtalic and 3-methoxybenzoic acid two different homophtalic acid derivatives were synthesized as starting materials. Then the corresponding acyl azide and isocyanate derivatives were generated which might further be used as a precursor to construct a variety of indole derivatives. After synthesizing urea derivatives, ring-closure under the basic conditions generated the heterocyclic units. Whole products were conscientiously purified and characterized.

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Chemistry.

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http://etd.lib.metu.edu.tr/upload/3/12611521/index.pdf
https://hdl.handle.net/11511/19132

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

A. A. Kılıklı, “Development of new synthetic methodologies for indole derivatives,” M.S. - Master of Science, Middle East Technical University, 2010.