Development of new synthetic methodologies for indole derivatives

Kılıklı, Ahmet Alper
Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besides this, another objective is to observe and discuss effects of two different substituents on the homophtalic acid system through the synthetic route. Initially starting from homophtalic and 3-methoxybenzoic acid two different homophtalic acid derivatives were synthesized as starting materials. Then the corresponding acyl azide and isocyanate derivatives were generated which might further be used as a precursor to construct a variety of indole derivatives. After synthesizing urea derivatives, ring-closure under the basic conditions generated the heterocyclic units. Whole products were conscientiously purified and characterized.


Investigation of thermal characteristics of naphthoxazines and polynaphthoxazines via pyrolysis mass spectrometry
Koyuncu, Zeynep; Hacaloğlu, Jale; Department of Chemistry (2009)
In this study, polymerization mechanisms of aromatic (C6H5 or C6F5) and alkyl (CH3, C2H5, C3H7, C6H13, C12H25 or C18H37) amine based naphthoxazine monomers (15-Na, 15Na-C1, 15Na-C2, 15Na-C3, 15Na-C6, 15Na-C12 and 15Na-C18) and thermal degradation mechanisms of polynaphthoxazines synthesized by curing the naphthoxazine monomers (P-15-Na, P-15NaF, P-15Na-C1, P-15Na-C2, P-15Na-C3, P-15Na-C6, P-15Na-C12 and P-15Na-C18) were studied by direct pyrolysis mass spectrometry. During the curing process, the evolutions...
Design and synthesis of near-ir emitting fluorescent chemosensors for transition metal ions
Kütük, İlker; Akkaya, Engin Umut; Department of Chemistry (2008)
Supramolecular chemistry is an emerging field of chemistry which has attracted much attention in recent years as a result of its broad applicability in many areas. Thus, the design of functional supramolecular systems is strongly in demand in this field. For this purpose, we have developed near-IR emitting ratiometric fluorescent chemosensors for transition metal ions. Judicious placement of dithiodioxaazamacrocycles on the BODIPY chromophore generates this chemosensor which is selective for Hg(II) ions and...
Darzens reaction of substituted alfa-bromo acetophenones with acyl phosphonates
Pirkin, Eser; Demir, Ayhan Sıtkı; Department of Chemistry (2008)
Phosphorous containing small cycles are very important building blocks in organic and medicinal chemistry. Many of their derivatives, especially cyclopropyl- and 1,2- epoxypropylphosphonates, have attracted great attention due to the broad spectrum of their biological properties including antiviral, anticancer, antibiotic, antibacterial, pesticidal, insecticidal and enzyme inhibitory activities. The Darzens condensation is one of the most potential methodologies for the preperation of α,β-epoxy carbonyl com...
Using the science writing heuristic approach to promote student understanding in chemical changes and mixtures
Kıngır, Sevgi; Geban, Ömer; Günel, Murat; Department of Secondary Science and Mathematics Education (2011)
The purpose of the present study was to investigate the effect of Science Writing Heuristic (SWH) approach on 9th grade students’ understanding of chemistry concepts and chemistry achievement in chemical changes and mixtures units. Four 9th grade classes taught by the two chemistry teachers from a public high school were selected for the study. Each teacher’s one intact class was assigned as the experimental group and the other class was assigned as the control group. Students in the experimental group were...
Development of new synthetic methodologies for the synthesis of unusual isocoumarin and indole derivatives:The chemistry of homophthalic acid
Özcan, Sevil; Balcı, Metin; Department of Chemistry (2007)
Many heterocyclic compounds containing nitrogen, oxygen and sulfur show wide range of physiological activities and their synthesis has always been attracted the interest of chemists. The aim of this research is to develop new synthetic methodologies leading to the synthesis of new derivatives of isocoumarines, indoles, isoquinolines, benzodiazepinones and quinazolines, which have been found to show important biological activities. Starting from homophthalic acid and bishomophthalic acid the corresponding ac...
Citation Formats
A. A. Kılıklı, “Development of new synthetic methodologies for indole derivatives,” M.S. - Master of Science, Middle East Technical University, 2010.