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Gemsitabin Yüklü Yarım Jenerasyon PAMAM Dendrimer Kaplı Manyetik Nanoparçacıkların Meme Kanseri Hücre Hatları Üzerindeki Sitotoksik Etkileri
Date
2016-02-24
Author
Parsian, Maryam
Mutlu, Pelin
Yalçın Azarkan, Serap
Tezcaner, Ayşen
Gündüz, Ufuk
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https://hdl.handle.net/11511/82883
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In this study, different types of magnetic nanoparticles were synthesized for treatment of breast cancer by targeted drug delivery. Polyamidoamine (PAMAM) dendrimer, Chitosan (CS) and Polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared and loaded with Gemcitabine. The loading efficiency of drug for various half generations of dendrimer coated magnetic nanoparticles (DcMNPs), Chitosan coated magnetic nanoparticles (CSMNPs) and Polyhydroxybutyrate magnetic nanoparticles (PHB-MNPs) were inves...
Genetic diversity of honey bee populations in Turkey based on microsatellite markers : a comparison between migratory versus stationary apiaries and isolated regions versus regions open to migratory beekeeping
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The honey bee (Apis mellifera L.) is a globally significant species of apparent economic and ecological importance. Recent reports from Spain, Italy and Greece point to an intense admixture of honey bee populations signified by a loss of population structure. This is mostly attributed to migratory beekeeping practices and replacement of queens or colonies with commercial ones that are usually from non-native races or hybrids of different subspecies. These two practices are also heavily carried out in parts ...
Derişik Katı-Sıvı Karışımlarında Hız Profilinin Ultrasonik Doppler Hız Ölçüm Tekniği Kullanılarak Analizi ve Hız Profilinden Bulut Yüksekliğinin Tayini
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Analysis of velocity profiles in concentrated solid-liquid mixtures using ultrasound doppler velocimetry
Taşkın, Ahmet Fırat; Ayrancı Tansık, İnci; Uludağ, Yusuf; Department of Chemical Engineering (2021-7)
Stirred tanks are widely used for a variety of processes in industry such as solid dispersion, crystallization and dissolution processes. Several parameters are used to optimize these stirred tank processes such as impeller type, tank geometry and impeller speed. The flow field in the stirred tank is complex and varies depending on these parameters. In these processes diffusion and chemical reaction rate depend on the flow field and velocity fluctuations; therefore, information about the flow field is valua...
Doksorubisin Bağlı Kitosan Kaplı Manyetik Nanoparçacıkların Meme Kanseri Hücre Hatları Üzerindeki Etkinliğinin İmmünositokimya Yöntemi İle Belirlenmesi
Gündüz, Ufuk; Yalcin, Serap; Unsoy, Gozde(2015-12-31)
Nanoparçacıkların kanser tedavisi, ilaç hedefleme ve kontrollü ilaç salım sistemlerinde kullanımı çalışmaları son zamanlarda artış göstermektedir. Nanoparçacıklar küçük boyutları sayesinde hücre içine kolay alınabilmekte ve çeşitli malzemelerle kaplanarak yüzey özellikleri değiştirilebilmektedir. Tümör hücrelerine hedeflendirilebilen manyetik nanoparçacıklar (MNP) kanser tanı ve tedavisinde kullanılmaktadır. Manyetik özellik taşıyan nanoparçacıklar, manyetik alan varlığında istenilen bölgeye hedeflenebilme ...
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M. Parsian, P. Mutlu, S. Yalçın Azarkan, A. Tezcaner, and U. Gündüz, “Gemsitabin Yüklü Yarım Jenerasyon PAMAM Dendrimer Kaplı Manyetik Nanoparçacıkların Meme Kanseri Hücre Hatları Üzerindeki Sitotoksik Etkileri,” 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/82883.