15 Lipoxygenase 1 expression inhibits angiogenesis in colorectal cancer cell lines

Tunçer, Sinem
Çimen, İsmail
Keskus, Ayşe
Duranel, Alper
Konu Karakayalı, Özlen
Ceyhan, Müşerref
Çolakoğlu, Melis
Yener, Caner
Banerjee, Sreeparna


15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
Cimen, I; Astarci, E; Banerjee, Sreeparna (Wiley, 2011-09-01)
15-Lipoxygenase-1 (15-LOX-1) is an enzyme of the inflammatory eicosanoid pathway whose expression is known to be lost in colorectal cancer (CRC). We have previously shown that reintroduction of the gene in CRC cell lines slows proliferation and induces apoptosis (Cimen et al. [2009] Cancer Sci 100: 2283-2291). We have hypothesized that 15-LOX-1 may be anti-tumorigenic by the inhibition of the antiapoptotic inflammatory transcription factor nuclear factor kappa B. We show here that ectopic expression of 15-L...
15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29.
Cimen, I; Tunçay, S; Banerjee, Sreeparna (Wiley, 2009-12-01)
Colorectal carcinoma (CRC) is often lethal when invasion and/or metastasis occur. 15-Lipoxygenase-1 (15-LO-1), a member of the inflammatory eicosanoid pathway, oxidatively metabolizes linoleic acid and its expression is repressed in CRC. In this study, we investigated the hypothesis that the lack of 15-LO-1 expression in CRC cells might contribute to tumorigenesis. Therefore we introduced 15-LO-1 into HCT-116 and HT-29 cells that do not have detectable levels of 15-LO-1. Our data indicate that expression of...
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1
Tuncer, Sinem; Keskus, Ayse Gokce; Colakoglu, Melis; Cimen, Ismail; Yener, Caner; KONU KARAKAYALI, ÖZLEN; Banerjee, Sreeparna (2017-11-01)
15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (RODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been shown to inhibit neoangiogenesis in colorectal cancer (CRC); in the present study we confirm this phenomenon and describe the mechanistic basis. We show that re-expression of 15-LOX-1 in CRC cell lines resulted in decreased transcriptional activity of HIF1 alpha and reduced the expression...
15-LOX-1 has diverse roles in the resensitization of resistant cancer cell lines to doxorubicin
Kazan, Hasan Huseyin; Urfali-Mamatoglu, Cagri; Yalcin, Gizem Damla; Bulut, Onur; Sezer, Abdullah; Banerjee, Sreeparna; Gündüz, Ufuk (2020-05-01)
Lipoxygenases (LOXs) are a family of enzymes that can oxygenate polyunsaturated fatty acids. As a member of the family, 15-lipoxygenase-1 (15-LOX-1) specifically metabolizes arachidonic acid and linoleic acid. 15-LOX-1 can affect physiological and pathophysiological events via regulation of the protein-lipid interactome, alterations in intracellular redox state and production of lipid metabolites that are involved in the induction and resolution of inflammation. Although several studies have shown that 15-L...
17 beta-estradiol induced compositional, structural and functional changes in rainbow trout liver, revealed by FT-IR spectroscopy: A comparative study with nonylphenol
Cakmak, G; Togan, İnci Zehra; Severcan, Feride (Elsevier BV, 2006-04-20)
Steroidal hormones produced by humans and animals are constantly being excreted into the environment. It has been demonstrated that sewage effluent discharged to surface water contains natural estrogens and synthetic estrogenic chemicals. As estrogen levels continuously increase in the aquatic environment, it is very important to have a detailed understanding of estrogens' effects on fish. In the present study, juvenile rainbow trout (Oncorhynchus mykiss) were exposed to 17 beta-estradiol (E2) for 3 weeks a...
Citation Formats
S. Tunçer et al., “15 Lipoxygenase 1 expression inhibits angiogenesis in colorectal cancer cell lines,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85925.