The role of genetic manipulation and in situ modifications on production of bacterial nanocellulose: A review

Date

2021-07-31

Author

Moradi, Mehran
Jacek, Paulina
Farhangfar, Azra
Guimarães, Jonas T.
Forough, Mehrdad

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Natural polysaccharides are well-known biomaterials because of their availability and low-cost, with applications in diverse fields. Cellulose, a renowned polysaccharide, can be obtained from different sources including plants, algae, and bacteria, but recently much attention has been paid to the microorganisms due to their potential of producing renewable compounds. In this regard, bacterial nanocellulose (BNC) is a novel type of nanocellulose material that is commercially synthesized mainly by Komagataeibacter spp. Characteristics such as purity, porosity, and remarkable mechanical properties made BNC a superior green biopolymer with applications in pharmacology, biomedicine, bioprocessing, and food. Genetic manipulation of BNC-producing strains and in situ modifications of the culturing conditions can lead to BNC with enhanced yield/productivity and properties. This review mainly highlights the role of genetic engineering of Komagataeibacter strains and co-culturing of bacterial strains with additives such as microorganisms and nanomaterials to synthesize BNC with improved functionality and productivity rate.

Subject Keywords

Bacterial cellulose, Biomaterials, Gluconacetobacter, Omics approaches, Response surface methodology

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85105290682&origin=inward
https://hdl.handle.net/11511/90518

Journal

International Journal of Biological Macromolecules

DOI

https://doi.org/10.1016/j.ijbiomac.2021.04.173

Collections

Department of Chemistry, Article

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Citation Formats

M. Moradi, P. Jacek, A. Farhangfar, J. T. Guimarães, and M. Forough, “The role of genetic manipulation and in situ modifications on production of bacterial nanocellulose: A review,” International Journal of Biological Macromolecules, pp. 635–650, 2021, Accessed: 00, 2021. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85105290682&origin=inward.