Aptamer Applications in Neuroscience

Ozturk, Meric
Nilsen-Hamilton, Marit
İlgü, Müslüm
Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, prion disease, or brain tumors. The diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theragnostic applications to meet these needs. This review covers pioneering studies in applying aptamers, which shows promise for future diagnostics and treatments of neurological disorders that pose increasingly dire worldwide health challenges.


Alternative Polyadenylation Patterns for Novel Gene Discovery and Classification in Cancer
BEGIK, Oguzhan; ÖYKEN, MERVE; ALICAN, Tuna Cinkilli; Can, Tolga; Erson Bensan, Ayşe Elif (2017-07-01)
Certain aspects of diagnosis, prognosis, and treatment of cancer patients are still important challenges to be addressed. Therefore, we propose a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden complexity in cancer transcriptomes, to further accelerate efforts to discover novel cancer genes and pathways. Here, we analyzed expression data for 1045 cancer patients and found a significant shift in usage of poly(A) signals in common tumor types (breast, colon, lung, prostate, gastric...
Flavin containing monooxygenase 3 genetic polymorphisms Glu158Lys and Glu308Gly and their relation to ischemic stroke
Ozcelik, Aysun Turkanoglu; Demirdogen, Birsen Can; Demirkaya, Seref; Adalı, Orhan (Elsevier BV, 2013-05-25)
Ischemic stroke is a multifactorial disease leading to severe long-term disability and it is the third leading cause of death in developed countries. Although many studies have been reported to elucidate etiological and pathological mechanisms of stroke, the genetic and molecular basis of disease remains poorly understood. Recent studies have shown that reactive oxygen species causing oxidative stress play a pivotal role in the pathogenesis of atherosclerosis that is the main cause of a group of cardiovascu...
Apolipoprotein a5 genetic polymorphisms in turkish population and the risk of ischemic stroke
Şahin, Esra; Adalı, Orhan; Department of Biotechnology (2008)
Stroke is the third leading cause of death and the most common cause of disabilities worldwide. Apolipoprotein A5 gene (APO A5), which encodes a 369 amino acid protein called Apolipoprotein AV (apo AV), has several single nucleotide polymorphisms (SNPs) found to be associated with altered triglyceride (TG) levels. Atherosclerosis is a major cause of ischemic stroke and this pathology may be associated with variability of TG levels. The main objective of this study was to investigate the coding region (c.553...
Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem (R)-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke
Ravina, Kristine; Briggs, Denise I.; Kışlal, Sezen; Warraich, Zuha; Nguyen, Tiffany; Lam, Rachel K.; Zarembinski, Thomas I.; Shamloo, Mehrdad (2018-12-01)
Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived neurotrophic factor (BDNF), delivered via an extended release HyStem (R)-C hydrogel implant or vehicle, on sensorimotor function, infarct volume, and neuroinflammation, following permanent distal middle cerebral artery occlusion (d...
Investigaton of chemopreventive properties of Urtica Dioica L., in MCF-7 and MDA231 breast cancer cell lines
Güler, Elif; İşcan, Mesude; Department of Biology (2011)
Cancer is a major health problem in developing world with mostly unsufficient treatment. Cancer prevention through dietary modification appears to be a practical and cost effective possibility. The aim of present study is to investigate the chemical components of “Urtica diocia,L (U. diocia) grown in Turkey” and the possible protective potential of its aqueous extract against breast cancer cell lines. U. diocia was extracted by maceration method which was performed for 6,12, 24, and 36 hours, at 50°C, 37°C,...
Citation Formats
M. Ozturk, M. Nilsen-Hamilton, and M. İlgü, “Aptamer Applications in Neuroscience,” PHARMACEUTICALS, vol. 14, no. 12, pp. 0–0, 2021, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/96011.