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Recent Submissions

A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
Sheraj, Ilir; Güray, N. Tülin; Banerjee, Sreeparna (2021-12-01)
© 2021, The Author(s).Recently, there has been a resurgence of interest in metabolic rewiring of tumors to identify clinically relevant genes. However, most of these studies have had either focused on individual tumors, or...
Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury
Ustaoglu, Sebnem Garip; Ali, Mohamed H. M.; Rakib, Fazle; Blezer, Erwin L. A.; Van Heijningen, Caroline L.; Dijkhuizen, Rick M.; Severcan, Feride (2021-12-01)
© 2021, The Author(s).Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI ...
Formaldehyde biosensing in air using fluorescent bacterial bioreporter cells
Elcin, Evrim; Ayaydin, Ferhan; Öktem, Hüseyin Avni (2021-11-01)
Formaldehyde is a genotoxic volatile organic pollutant and one of the causative agents of sick building syndrome. Despite of its hazardous carcinogenic effects, it has been still used in daily life products and household m...
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.
Cicek, Esra; Circir, Ayca; Oyken, Merve; Akbulut Caliskan, Ozge; Dioken, Didem Naz; Guntekin Ergun, Sezen; Cetin-Atalay, Rengul; Sapmaz, Aysegul; Ovaa, Huib; Sahin, Ozgur; Erson Bensan, Ayşe Elif (2021-10-30)
Epidermal growth factor receptor (EGFR) has critical roles in epithelial cell physiology. Over-expression and over-activation of EGFR have been implicated in diverse cancers, including triple-negative breast cancers (TNBCs...
Directed Differentiation of Mouse Embryonic Stem Cells to Mesoderm, Endoderm, and Neuroectoderm Lineages.
Balbasi, Emre; Sezginmert, Dersu; Alganatay, Ceren; Terzi Cizmecioglu, Nihal (2021-10-06)
Phylogeography and phylogeny of genus Quercus L. (Fagaceae) in Turkey implied by variations of trnT (UGU) -L (UAA) -F (GAA) chloroplast DNA region
Tekpinar, Ayten Dizkirici; AKTAŞ, CANER; Kansu, Çiğdem; DUMAN, HAYRİ; Kaya, Zeki (2021-10-01)
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.The genus Quercus L. is one of the most abundant and important genera of woody plants in the Northern Hemisphere as we...
Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.
Sen, Edanur; Kota, Krishna P; Panchal, Rekha G; Bavari, Sina; Kiriş, Erkan (2021-09-27)
A prelude to the proximity interaction mapping of CXXC5
Ayaz, Gamze; Turan, Gizem; Olgun, Çağla Ece; Kars, Gizem; Karakaya, Burcu; Yavuz, Kerim; Demiralay, Oyku Deniz; Can, Tolga; Muyan, Mesut; Yasar, Pelin (2021-09-01)
CXXC5 is a member of the zinc-finger CXXC family proteins that interact with unmodified CpG dinucleotides through a conserved ZF-CXXC domain. CXXC5 is involved in the modulation of gene expressions that lead to alterations...
Association of cholesterol 7 alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population
SEZER, EDA; CAN DEMİRDÖĞEN, BİRSEN; Demirkaya, Seref; Bulut, Giray; Akkulak, Merve; EVİN, EMRE; Adalı, Orhan (2021-09-01)
Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7 alpha-hydr...
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infection
YILMAZ, İSMAİL CEM; et. al. (2021-09-01)
Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes the development and immunogenicity of SARS-CoV-2 VLP v...
Achieving global equity for COVID-19 vaccines: Stronger international partnerships and greater advocacy and solidarity are needed
Figueroa, J. Peter; et. al. (2021-09-01)
Peter Figueroa and co-authors advocate for equity in the worldwide provision of COVID-19 vaccines.
Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic
Hotez, Peter J.; et. al. (2021-09-01)
A Lancet Commission for COVID-19 task force is shaping recommendations to achieve vaccine and therapeu-tics access, justice, and equity. This includes ensuring safety and effectiveness harmonized through robust sys-tems of...
Decadal changes in size, salinity, waterbirds, and fish in lakes of the Konya Closed Basin, Turkey, associated with climate change and increasing water abstraction for agriculture
Yilmaz, Gultekin; Colak, Mehmet Arda; Özgencil, İbrahim Kaan; Metin, Melisa; Korkmaz, Mustafa; Ertugrul, Serhat; Soyluer, Melisa; Bucak, Tuba; Tavsanoglu, U. Nihan; Özkan, Korhan; Akyürek, Sevda Zuhal; Beklioğlu, Meryem; Jeppesen, Erik (2021-08-09)
The Konya Closed Basin (KCB) in Turkey has a cold semiarid to warm Mediterranean climate and hosts the largest Turkish freshwater lake, Lake Beysehir, and the iconic saline Lake Tuz. Using published as well as our own grou...
Ste2p Under the Microscope: the Investigation of Oligomeric States of a Yeast G Protein-Coupled Receptor
CEVHEROĞLU, ORKUN; Murat, Merve; Mingu-Akmete, Sara; Son, Çağdaş Devrim (2021-08-01)
Oligomerization of G protein-coupled receptors (GPCRs) may play important roles in maturation, internalization, signaling, and pharmacology of these receptors. However, the nature and extent of their oligomerization is sti...
Updated-extended molecular time and molecular phylogeny of Gundelia species native to Turkey
Fırat, Mehmet; Ateş, Mevlüde Alev; Kaya, Zeki (2021-08-01)
Generally, Gundelia tournefortii is considered as the sole representative of the genus and the other species of Gundelia as synonyms. Recent studies suggest that the genus is rich with 22 species. Off these, thirteen are e...
miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A
Noyan, Senem; Andaç Özketen, Ayşe; Gurdal, Hakan; Gur Dedeoglu, Bala (2021-07-01)
© 2021 Elsevier Inc.MicroRNAs (miRNAs) are shown to regulate various processes in cancer like motility and invasion that are key features of the metastatic triple negative breast cancer (TNBCs). Epithelial-mesenchymal tran...
Investigation of the effects of nutrient restriction on endolysosomal signaling in colorectal cancer (CRC) cells.
Gulec, Aliye E.; Hüsnügil, Hepşen Hazal; Oral, Goksu; Sheraj, Ilir; Banerjee, Sreeparna (2021-07-01)
A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2 Receptor
Rajpoot, Sajjan; Ohishi, Tomokazu; Kumar, Ashutosh; Pan, Qiuwei; Banerjee, Sreeparna; Zhang, Kam Y. J.; Baig, Mirza S. (2021-07-01)
Background and Objective Coronavirus disease 2019 is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first detected in December 2019 and has since been declared a pand...
Applications and potential of genome-editing systems in rice improvement: Current and future perspectives
Tabassum, Javaria; Ahmad, Shakeel; Hussaın, Babar; Mawia, Amos Musyoki; Zeb, Aqib; Ju, Luo (2021-07-01)
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Food crop production and quality are two major attributes that ensure food security. Rice is one of the major sources of food that feeds half of the world’s populati...
Combined drought and heat stresses trigger different sets of miRNAs in contrasting potato cultivars
Gokce, Zahide Neslihan Ozturk; Aksoy, Emre; Bakhsh, Allah; Demirel, Ufuk; Caliskan, Sevgi; Caliskan, Mehmet Emin (2021-07-01)
MicroRNAs are small, non-coding RNAs that are responsible for regulation of gene expression during plant growth and development. Although there are many studies on miRNAs in other plants, little work has been done to under...
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