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Recent Submissions

Hydrological period conversions induce micro-eukaryotic community homogenization along the eastern route of China's South-to-North Water Diversion Project Peng, Kai; Qin, Zhirui; Feng, Tao; Jeppesen, Erik; Wei, Jiahao; Liu, Jiayuan; Cai, Yongjiu; Gong, Zhijun (2026-03-01) How hydrological period conversions, including the water diversion period (WDP) and flood discharge period (FDP), influence microbial communities, their assembly mechanisms, and community stability remains poorly understoo...
M2 macrophage-derived extracellular vesicles induce EMT-like transcriptional reprogramming in colorectal cancer cells via upregulation of FAM83A. Isik, Melis; Akkulak, Merve; Derkus, Burak (2026-02-19)
Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice Zhang, Yulin; et. al. (2026-02-11) Glioblastoma (GBM) remains a highly lethal form of cancer due to its molecular heterogeneity and the immunosuppressive microenvironment surrounding the tumor. Here, we report a modular immunotherapy platform characterized ...
Insight into greenhouse gas emission in freshwater aquaculture ponds in Jiangsu Province: Variation due to species used and ponds management practice Li, Yifan; Wang, Hongyu; Zeng, Qingfei; Jeppesen, Erik; Gu, Xiaohong; Yan, Jie (2026-02-01) Aquaculture ponds have emerged as a significant contributor to greenhouse gas (GHG) emissions. We measured methane (CH4), carbon dioxide (CO2), and nitrous oxide (N2O) emissions in ponds, all located in Jiangsu Province, w...
Api-TRACE: A system for honey bee tracking in a constrained environment to study bee learning process and the effect of lithium on learning Erdem, Babür; Ince, Ayben; SEVİN, SEDAT; Arslan, Okan Can; Gözen, Ayşe Gül; Giray, Tugrul; Alemdar, Hande (2026-02-01) Learning is an adaptive behavior that improves the performance of bees in foraging, dance communication, predator avoidance, and other tasks. Any deficiencies in learning could be detrimental to the long-term survival of t...
Larger crustacean zooplankton thrive at lower temperatures and under reduced predation in pond ecosystems Rincon-Palau, Katterine; Badosa, Anna; Avci, Feride; Bartrons, Mireia; Beklioğlu, Meryem; Boix, Dani; Cuenca-Cambronero, Maria; Davidson, Thomas A.; Lacerot, Gissell; Lemmens, Pieter; Martin, Luis; Meerhoff, Mariana; Mehner, Thomas; Wijns, Robby; Brucet, Sandra (2026-01-26) Body size is a fundamental trait influencing ecological functions, trophic dynamics, and organismal fitness across ecosystems. However, the environmental drivers shaping body size patterns in pond ecosystems across broad s...
Diet and Mobility in Byzantine Western Anatolia: Carbon and Nitrogen Isotopic Ratios and Ancient DNA Evidence from Barcın Höyük and Kadıkalesi Anaia Ozbal, Rana; BÜYÜKKARAKAYA, ALİ METİN; UYSAL, GÜLFEM; Butun, Erge; Gerritsen, Fokke; Akbaba, Ali; ALTINIŞIK, NEFİZE EZGİ; Somel, Mehmet (2026-01-20) This study presents the integrated results of stable carbon (delta 13C) and nitrogen (delta 15N) isotope and aDNA analyses, conducted to examine dietary and mobility practices in two mid- to late Byzantine communities in w...
Patient-derived tumor organoids: advances, applications, and future directions in biomedical research Acar, Ahmet (2026-01-01) Patient-derived tumor organoids (PDTOs) have become a key tool in cancer and translational oncology because they are physiologically relevant, 3D in vitro systems that preserve the genetic, epigenetic and phenotypic featur...
The role of pondscapes in supporting identities Benejam, Lluís; et. al. (2026-01-01) This study investigates how pondscapes, networks of ponds, and their surrounding environments contribute to supporting identities across diverse cultural contexts. Supporting identities is a non-material Nature’s Contribut...
Genome-wide association study of common bean (Phaseolus vulgaris L.) unveils novel loci governing root-to-seed zinc allocation ALTAF, MUHAMMAD TANVEER; Nadeem, Muhammad Azhar; Ayten, Sefa; Aksoy, Emre; Mansoor, Sheikh; Karunathilake, E.M.B.M.; Chung, Yong Suk; Baloch, Faheem Shehzad (2025-12-01) Micronutrient malnutrition is a global health concern, highlighting the importance of essential micronutrients like zinc in human diet, and enhancing zinc concentration in staple crops like common beans is a promising stra...
A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor Kurt, Han; Akyol, Ali; Son, Çağdaş Devrim; Zheng, Chen; Gado, Irene; Meli, Massimiliano; Ferrandi, Erica Elisa; Bassanini, Ivan; Vasile, Francesca; Gurevich, Vsevolod V.; Nebol, Aylin; Cagavi, Esra; Morra, Giulia; Sensoy, Ozge (2025-12-01) Excessive signaling by various GPCRs underlies a variety of human disorders. Suppression of GPCRs by “enhanced” arrestin mutants was proposed as therapy. We hypothesized that GPCR binding of endogenous arrestins can be inc...
3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells Almeric, Elanur; Karagozoglu, Deniz; Cicek, Mustafa; Dioken, Didem Naz; Tac, Huseyin Avni; Cicek, Esra; Kirim, Busra Aytul; Gurcuoglu, Irmak; Sezerman, Osman Ugur; Ozlu, Nurhan; Erson Bensan, Ayşe Elif (2025-12-01) Epitranscriptomic changes in the transcripts of cancer related genes could modulate protein levels. RNA editing, particularly A-to-I(G) editing catalyzed by ADAR1, has been implicated in cancer progression. RNA editing eve...
Thermal power plant proximity alters Olive composition and induces cytotoxicity in human cells Gürbüz, Esra; Aksoy, Emre; Sandallı, Aytül; BİLGİLİ TETİKOĞLU, FUNDA; Şeker, Enes; Kıran, Naciye Nisa; Tetikoğlu, Sinan; MURATOĞLU, HACER; Kaya, Muhammed Fatih; AKYÜZ TURUMTAY, EMİNE; Çelik Uzuner, Selcen (2025-12-01) Thermal power plants (TPPs) are essential for meeting increasing energy demands, but they also pose significant environmental and health risks. The Yatağan TPP in Türkiye is located near agricultural and residential areas,...
Association of nesting Otus scops (Eurasian Scops Owl) with Xerotyphlops vermicularis (worm snake) in Türkiye Gocer, Elif; Johnson, David H.; Bilgin, Cemal Can; Vrezec, Al (2025-11-24) We report the discovery of a novel relationship between Otus scops (Eurasian Scops Owl) and Xerotyphlops vermicularis (worm snake) found during systematic nest box inspections spanning 6 breeding seasons in central T & uum...
Addressing the specific roles of histone modifications in transcriptional repression. Hedehus, Lin; Mas, Aina M; Alpsoy, Aktan; Armstrong, Robin L; Koche, Richard; Tatar, Tülin; Wang, Hua; Helin, Kristian (2025-11-22) Our understanding of epigenetic processes is based on the hypothesis that individual posttranslational modifications of DNA and histones, or combina- tions thereof, function to direct unique downstream effects on transcrip...
Climate and habitat types drive avian communities of the Anatolian Diagonal Gurol, Ilgin Ertan; Ambarlı, Didem; Zeydanli, Ugur (2025-11-03) Avian diversity is experiencing alarming declines across the globe. Still, several biodiversity hotspots remain to be studied in terms of avian communities. At the convergence of three global biodiversity hotspots lies the...
Diverse Foraging in Small-Bodied Fishes: Effects on Water Quality and Submerged Macrophytes in Shallow Subtropical Lake Ecosystems Guo, Chao; Li, Wei; Hansen, Adam G.; Li, Shiqi; Ke, Jie; Jeppesen, Erik; Liao, Chuansong; Yuan, Jing; Zhang, Tanglin; Guo, Chuanbo; Liu, Jiashou (2025-11-01) The proliferation of small-bodied fishes and their foraging effects within food webs can limit the growth of submerged macrophytes and degrade water quality in shallow lake ecosystems. The foraging habits of small-bodied f...
Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3 Alpsoy, Aktan; Ipsaro, Jonathan J.; Skopelitis, Damianos; Pal, Sujay; Chung, Frank S.; Carpenter, Shannon; Desmarais, John J.; Wu, Xiaoli S.; Chang, Kenneth; DiMare, Matthew T.; Harten, Erin; Bergman, Staci; Kinney, Justin B.; Engelman, Jeffrey A.; Bhang, Hyo-Eun C.; Joshua-Tor, Leemor; Vakoc, Christopher R. (2025-11-01) The transcription factor POU2F3 defines the identity of tuft cells and underlies a distinct molecular subtype of small cell lung cancer (SCLC). Although POU2F3 is considered undruggable, its activity critically depends on ...
Dissecting Trends in the Latitudinal Diversity Gradient of Benthic Macroinvertebrates in Freshwater Lakes Across Scales He, Hu; Zhang, You; Li, Yan; Peng, Kai; Rutter, Robert P.; Jyväsjärvi, Jussi; Hämäläinen, Heikki; Ntislidou, Chrysoula; Wang, Jianjun; Zhang, Min; Li, Kuanyi; Liu, Zhengwen; Johansson, Liselotte S.; Søndergaard, Martin; Cai, Yongjiu; Wang, Haijun; Jeppesen, Erik; Chase, Jonathan M. (2025-10-01) The latitudinal diversity gradient is one of the most striking biogeographical patterns on Earth and typically reveals increases in species richness from the poles towards the tropics. However, the latitudinal diversity pa...
Single-cell transcriptional profiling in Arabidopsis root exposed to boron toxicity at seedling stages Kayıhan, Ceyhun; Kocakaya, Ebru; KAYMAZ, YASİN; Yilmaz, Hikmet; Ünal, Halis Batuhan; Yaprak, Oğuzhan; Aksoy, Emre; Karagöz, Dilara Sedef (2025-10-01) Cell-specific transcriptional responses to environmental stimuli are yet to be fully characterized. Single-cell sequencing technology allows us to analyze different cell types under different conditions. Here, high-through...

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