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Insect decline in forests depends on species’ traits and may be mitigated by management Staab, Michael; Gossner, Martin M.; Simons, Nadja K.; Achury, Rafael; Ambarlı, Didem; Bae, Soyeon; Schall, Peter; Weisser, Wolfgang W.; Blüthgen, Nico (2023-12-01) Insects are declining, but the underlying drivers and differences in responses between species are still largely unclear. Despite the importance of forests, insect trends therein have received little attention. Using 10 ye...
The indispensability of macrophage adaptor proteins in chronic inflammatory diseases Atre, Rajat; Sharma, Rahul; Vadim, Gaponenko; Solanki, Kundan; Wadhonkar, Khandu; Singh, Neha; Patidar, Pramod; Khabiya, Rakhi; Samaur, Harshita; Banerjee, Sreeparna; Baig, Mirza S. (2023-06-01) Adaptor proteins represent key signalling molecules involved in regulating immune responses. The host's innate immune system recognizes pathogens via various surface and intracellular receptors. Adaptor molecules are centr...
EGFR endocytosis: more than meets the eye Sapmaz, Aysegul; Erson Bensan, Ayşe Elif (2023-04-10)
A New Species of Evolvulus (Convolvulaceae) with Golden Hairs from the Brazilian Cerrado Santos, Diego; Alves Amorım, Cıhelıo; Buril, Maria Teresa (2023-03-28) A new species of Evolvulus from the Brazilian Cerrado, a savanna biodiversity hotspot, is described here. Evolvulus aureus sp. nov. is similar to E. passerinoides, both found in Cerrado, and share erect stems (also decumbe...
The recovery effect of Vitamin C on structural alterations due to Streptozotocin-Induced diabetes in rat testicular tissues Küçük Baloğlu, Fatma; Guldag Tas, Damla; Yilmaz, Okkes; Severcan, Feride (2023-03-05) Type I Diabetes is a multisystem disease that causes alterations in carbohydrate, protein, and fat metabolisms due to hyperglycemia. It has an extensive pathology, especially the mechanism involving oxidative stress is sti...
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors Zapata, Luis; Caravagna, Giulio; Williams, Marc J.; Lakatos, Eszter; Abduljabbar, Khalid; Werner, Benjamin; Chowell, Diego; James, Chela; Gourmet, Lucie; Milite, Salvatore; Acar, Ahmet; Riaz, Nadeem; Chan, Timothy A.; Graham, Trevor A.; Sottoriva, Andrea (2023-03-01) In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356 immune-checkpoint-treated metastases using immune dN/dS, the ratio of nonsynonymous to synonymo...
Pan-Cancer Analysis of the COVID-19 Causal Gene SLC6A20 Acar, Ahmet (2023-03-01)
Specific Functions of Melanocortin 3 Receptor (MC3R) Yanık, Tülin; Durhan, Seyda Tugce (2023-02-27) Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date. In addition to its function regarding the weight gain and appet...
Zn doped CaP coatings used for controlling the degradation rate of MgCa1 alloy: In vitro anticorrosive properties, sterilization and bacteria/cell-material interactions Schmidt, Jürgen; Pana, Iulian; Bystrova, Anna; Dinu, Mihaela; Dekhtyar, Yuri; Vitelaru, Catalin; Gorohovs, Marks; Marinescu, Ioana Maria; HURİ, PINAR; Tamay, Dilara Goksu; Juravlea, Gabriela Andreea; Buyuksungur, Senem; Parau, Anca Constantina; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Vladescu, Alina (2023-02-01) The purpose of this study was to investigate the effect of Zn doped CaP coatings prepared by micro-arc oxidation method, as a possible approach to control MgCa1 alloy degradation. All the prepared coatings comprised a calc...
Versatile RNA: overlooked gems of the transcriptome. Erdem, Murat; Cicek, Mustafa; Erson Bensan, Ayşe Elif (2023-01-31) The critical role of RNA, its use and targetability concerning different aspects of human health are gaining more attention because our understanding of the versatility of RNA has dramatically evolved over the last decades...
Mobility and kinship in the world's first village societies Pearson, Jessica; Evans, Jane; Lamb, Angela; Baird, Douglas; Hodder, Ian; Marciniak, Arkadiusz; Larsen, Clark Spencer; Knüsel, Christopher J.; Haddow, Scott D.; Pilloud, Marin A.; Bogaard, Amy; Fairbairn, Andrew; Plug, Jo-Hannah; Mazzucato, Camilla; Mustafaoğlu, Gökhan; Feldman, Michal; Somel, Mehmet; Fernández-Domínguez, Eva (2023-01-24) Around 10,000 y ago in southwest Asia, the cessation of a mobile lifestyle and the emergence of the first village communities during the Neolithic marked a fundamental change in human history. The first communities were sm...
Comprehensive Evaluation of Three Important Herbs for Kombucha Fermentation Öztürk, Burcu Emine Tefon; Eroğlu, Berfin; Delik, Eda; Çiçek, Mustafa; Çiçek, Esra (2023-01-01) Research background. Kombucha is consumed worldwide for its beneficial health effects. Kombucha teas fermented with various herbal infusions have become very important nowadays. Although black tea is used for kombucha ferm...
In vitro cytotoxicity, corrosion and antibacterial efficiencies of Zn doped hydroxyapatite coated Ti based implant materials Buyuksungur, Senem; YILGÖR HURİ, PINAR; Schmidt, Jürgen; Pana, Iulian; Dinu, Mihaela; Vitelaru, Catalin; Kiss, Adrian E.; Tamay, Dilara Goksu; Hasırcı, Vasıf Nejat; Vladescu, Alina; Nesrin Hasirci, Hasirci (2023-01-01) Ti6Al4V alloy is successfully used as implant material in dental and orthopedic surgeries for years due to its much better compatibility, lower density, corrosion resistance, etc. compared to the other metals. Meantime, mo...
Boron toxicity induces sulfate transporters at transcriptional level in Arabidopsis thaliana Kayihan, Ceyhun; Aksoy, Emre; Mutlu, Su Naz (2023-1-01) Plants activate glutathione (GSH)-dependent detoxification pathways at biochemical and molecular levels under boron (B) toxicity. Sulfate uptake and transport are necessary for GSH biosynthesis in plants. Therefore, the tr...
Challenges and opportunities in the use of ponds and pondscapes as Nature-based Solutions Cuenca-Cambronero, M.; et. al. (2023-1-01) Ponds and “pondscapes” (networks of ponds) are crucial habitats for biodiversity and for delivering multiple benefits to humans, so-called “Nature’s Contribution to People”, such as climate mitigation and adaptation to cli...
Spatial and temporal heterogeneity in human mobility patterns in Holocene Southwest Asia and the East Mediterranean. Koptekin, Dilek; et. al. (2022-12-06) We present a spatiotemporal picture of human genetic diversity in Anatolia, Iran, Levant, South Caucasus, and the Aegean, a broad region that experienced the earliest Neolithic transition and the emergence of com- plex hie...
New insights on commemoration of the dead through mortuary and architectural use of pigments at Neolithic Çatalhöyük, Turkey Schotsmans, E.M.J.; Busacca, G.; Lin, S.C.; Vasić, M.; Lingle, A.M.; Veropoulidou, R.; Mazzucato, C.; Tibbetts, B.; Haddow, S.D.; Somel, Mehmet; Toksoy-Köksal, F.; Knüsel, C.J.; Milella, M. (2022-12-01) The cultural use of pigments in human societies is associated with ritual activities and the creation of social memory. Neolithic Çatalhöyük (Turkey, 7100–5950 cal BC) provides a unique case study for the exploration of li...
Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients Turan, Zeliha Gözde; Richter, Vincent; Bochmann, Jana; Parvizi, Poorya; Yapar, Etka; Işıldak, Ulas; Waterholter, Sarah-Kristin; Leclere-Turbant, Sabrina; Son, Çağdaş Devrim; Duyckaerts, Charles; Yet, İdil; Arendt, Thomas; Somel, Mehmet; Ueberham, Uwe (2022-12-01) The possible role of somatic copy number variations (CNVs) in Alzheimer’s disease (AD) aetiology has been controversial. Although cytogenetic studies suggested increased CNV loads in AD brains, a recent single-cell whole-g...
Bitki Peptit ve Amino Asit Taşıyıcılarının Demir Taşınmasındaki Görevleri Aksoy, Emre; MAQBOOL, AMIR; YERLİKAYA, BAYRAM ALİ; WAHID, FAZLI (2022-12-01)
Two formulations of coronavirus disease-19 recombinant subunit vaccine candidate made up of S1 fragment protein P1, S2 fragment protein P2, and nucleocapsid protein elicit strong immunogenicity in mice Özcengiz, Erkan; Keser, Duygu; Özcengiz, Gülay; Çelik, Gözde; ÖZKUL, AYKUT; İnçeh, Fatma Nur (2022-12-01) Coronavirus disease (COVID-19) is ongoing as a global epidemic and there is still a need to develop much safer and more effective new vaccines that can also be easily adapted to important variants of the pathogen. In the p...

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