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Recent Submissions

Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury Ustaoglu, Sebnem Garip; Ali, Mohamed H. M.; Rakib, Fazle; Blezer, Erwin L. A.; Van Heijningen, Caroline L.; Dijkhuizen, Rick M.; Severcan, Feride (2021-12-01) © 2021, The Author(s).Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI ...
miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A Noyan, Senem; Andaç Özketen, Ayşe; Gurdal, Hakan; Gur Dedeoglu, Bala (2021-07-01) © 2021 Elsevier Inc.MicroRNAs (miRNAs) are shown to regulate various processes in cancer like motility and invasion that are key features of the metastatic triple negative breast cancer (TNBCs). Epithelial-mesenchymal tran...
Variable kinship patterns in Neolithic Anatolia revealed by ancient genomes Yaka, Reyhan; et. al. (2021-06-01)
Generation and characterization of human induced pluripotent stem cell line METUi001-A from a 25-year-old male patient with relapsing-remitting multiple sclerosis Begentaş, Onur Can; Koc, Dilara; Yurtogullari, Sukran; Temel, Musa; Akcali, Kamil Can; Demirkaya, Seref; Kiriş, Erkan (2021-05-01) © 2021Multiple sclerosis is a chronic disease characterized by inflammation, demyelination, and axonal damage in the central nervous system. Here, we established an induced pluripotent stem cell (iPSC) line METUi001-A from...
Determinants of phytoplankton size structure in warm, shallow lakes ERDOĞAN, ŞEYDA; Beklioğlu, Meryem; Litchman, Elena; Miller, Elizabeth T.; Levi, Eti E.; Bucak, Tuba; Tavşanoǧlu, Ülkü Nihan (2021-05-01) © 2021 The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.Body size is an important trait of any organism, including phytoplankton, be...
Inhibition of Wnt signalling by Notch via two distinct mechanisms. Acar, Ahmet; Hidalgo-Sastre, Ana; Leverentz, Michael K; Mills, Christopher G; Woodcock, Simon; Baron, Martin; Collu, Giovanna M; Brennan, Keith (2021-04-27)
Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers? A Brief Overview. Di Fiore, Riccardo; Suleiman, Sherif; Pentimalli, Francesca; O’toole, Sharon A.; O’leary, John J.; Ward, Mark P.; Conlon, Neil T.; Sabol, Maja; Ozretić, Petar; Erson Bensan, Ayşe Elif; Reed, Nicholas; Giordano, Antonio; Herrington, C. Simon; Calleja-Agius, Jean (2021-04-07) © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Gynecological cancers pose an important public health issue, with a high incidence among women of all ages. Gynecological cancers such as malignant germ-cell tumors,...
Demography of swordfish (Xiphias gladius Linneus) populations from the coasts of Turkey, based on mitochondrial DNA and microsatellites Yuncu, Eren; Acan, Sinan Can; ONAR, Vedat; Karakulak, F. Saadet; GÖKOĞLU, MEHMET; Alicli, Turgut Zahit; Chiriboga, Fidel; Togan, İnci Zehra; Ozer, Fusun (2021-03-01) The genetic diversity of the Mediterranean swordfish (Xiphias gladius Linneus) has not been explored extensively at its easternmost range so far. In this study, modern X. gladius samples from the eastern part of the Medite...
Editorial: Metal Transport in Plants Clemens, Stephan; Eroğlu, Seçkin; Grillet, Louis; Nozoye, Tomoko (2021-02-26)
Million-year-old DNA sheds light on the genomic history of mammoths van der Valk, Tom; et. al. (Springer Science and Business Media LLC, 2021-2-17) Temporal genomic data hold great potential for studying evolutionary processes such as speciation. However, sampling across speciation events would, in many cases, require genomic time series that stretch well back into th...
Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation. Güven, Gözde; Terzi Çizmecioğlu, Nihal (2021-02-09) Cell division and death play an important role in embryonic development. Cell specialization is accompanied with slow proliferation and quiescence. Cell death is important for morphogenesis. Gene expression changes during ...
Identification of Potential Therapeutic Genes and Pathways in Phytoestrogen Emodin Treated Breast Cancer Cell Lines via Network Biology Approaches Sakalli-Tecim, Elif; Uyar-Arpaci, Pembegul; Güray, Nülüfer Tülün (2021-02-01) Phytoestrogens have been investigated for their potential anti-tumorigenic effects in various cancers including breast cancer. Emodin being a phytoestrogen shows anti-carcinogenic properties especially in estrogen receptor...
Nutrient Loading, Temperature and Heat Wave Effects on Nutrients, Oxygen and Metabolism in Shallow Lake Mesocosms Pre-Adapted for 11 Years Jeppesen, Erik; Audet, Joachim; Davidson, Thomas A.; Neif, Erika M.; Cao, Yu; Filiz, Nur; Lauridsen, Torben L.; Larsen, Soren E.; Beklioğlu, Meryem; Sh, Tserenpil; Sondergaard, Martin (2021-01-01) Global changes (e.g., warming and population growth) affect nutrient loadings and temperatures, but global warming also results in more frequent extreme events, such as heat waves. Using data from the world's longest-runni...
Stepwise Reversal of Immune Dysregulation Due to STAT1 Gain-of-Function Mutation Following Ruxolitinib Bridge Therapy and Transplantation Kayaoğlu, Başak; Kasap, Nurhan; Yilmaz, Naz Surucu; Charbonnier, Louis Marie; Geckin, Busranur; Akcay, Arzu; Eltan, Sevgi Bilgic; Ozturk, Gulyuz; ÖZEN, AHMET OĞUZHAN; Karakoc-Aydiner, Elif; Chatila, Talal A.; Gürsel, Mayda; BARIŞ, SAFA (2021-01-01) Purpose Patients with heterozygous gain-of-function (GOF) mutations in STAT1 frequently exhibit chronic mucocutaneous candidiasis (CMC), immunodeficiency and autoimmune manifestations. Several treatment options including t...
Vitamin E Derivative with Modified Side Chain Induced Apoptosis by Modulating the Cellular Lipids and Membrane Dynamics in MCF7 Cells Gok, Seher; Kuzmenko, Oleksandr; Babinskyi, Andrii; Severcan, Feride (Springer Science and Business Media LLC, 2021-01-01) The vitamin E derivative with side chain modification (TC6OAc) has been shown to possess anticancer activity in our earlier in vivo studies. It was hypothesized that, as Vitamin E (VE) and VE derivative are fat soluble lip...
Proteomic Analysis of a hom-Disrupted, Cephamycin C Overproducing Streptomyces clavuligerus Unsaldi, Eser; KURT KIZILDOĞAN, ASLIHAN; ÖZCAN, SERVET; Becher, Dorte; Voigt, Birgit; Aktas, Caner; Özcengiz, Gülay (2021-01-01) Background: Streptomyces clavuligerus is prolific producer of cephamycin C, a medically important antibiotic. In our former study, cephamycin C titer was 2-fold improved by disrupting homoserine dehydrogenase (hom) gene of...
Human population dynamics and Yersinia pestis in ancient northeast Asia Kilinc, Gulsah Merve; et. al. (2021-01-01) We present genome-wide data from 40 individuals dating to c.16,900 to 550 years ago in northeast Asia. We describe hitherto unknown gene flow and admixture events in the region, revealing a complex population history. Whil...
Allergen fragrance molecules: a potential relief for COVID-19 Aydin, Asli Deniz; Altinel, Faruk; Erdogmus, Hueseyin; Son, Çağdaş Devrim (2021-01-01) BackgroundThe latest coronavirus SARS-CoV-2, discovered in China and rapidly spread Worldwide. COVID-19 affected millions of people and killed hundreds of thousands worldwide. There are many ongoing studies investigating d...
Arid4b physically interacts with Tfap2c in mouse embryonic stem cells Keskin, Ezgi Gul; Huang, Jialiang; Terzi Çizmecioğlu, Nihal (2021-01-01) Precise regulation of gene expression is required for embryonic stem cell (ESC) differentiation. Transcription factor (TF) networks coordinate the balance of pluripotency and differentiation in response to extracellular an...
The assessment of boron toxicity tolerance in F6 RILs of durum wheat [Triticum turgidum (L.) Tell. convar. durum (Desf.) Mackey] Göçmen Taşkın, Belgin; Özbek, Özlem; Keskin Şan, Sibel; Nachit, Miloudi Mikael; Kaya, Zeki (2021-01-01) © 2021, Akadémiai Kiadó Zrt.The identification of new genotypes tolerant to the boron toxicity is very important for the breeding programs carried out in the arid and semiarid regions of West Asia and North Africa region. ...

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