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3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells Almeric, Elanur; Karagozoglu, Deniz; Cicek, Mustafa; Dioken, Didem Naz; Tac, Huseyin Avni; Cicek, Esra; Kirim, Busra Aytul; Gurcuoglu, Irmak; Sezerman, Osman Ugur; Ozlu, Nurhan; Erson Bensan, Ayşe Elif (2025-12-01) Epitranscriptomic changes in the transcripts of cancer related genes could modulate protein levels. RNA editing, particularly A-to-I(G) editing catalyzed by ADAR1, has been implicated in cancer progression. RNA editing eve...
Cyanobacterial blooms specifically alter the dispersal-mediated taxonomic and functional vertical similarity of microbial communities in a subtropical reservoir Li, Shuzhen; Yan, Xue; Chen, Huihuang; Jeppesen, Erik; Xiao, Peng; Jin, Lei; Xu, Zijie; Zuo, Jun; Ren, Kexin; Yang, Jun (2025-08-01) Harmful cyanobacterial blooms, including Raphidiopsis raciborskii (basionym Cylindrospermopsis raciborskii), are an increasing environmental concern in freshwater ecosystems globally. However, the ecological consequences o...
Low-dose natural clay Kaolin promotes the growth of submerged macrophytes and alters the rhizosphere microorganism community: Implications for lake restoration Sun, Shangsheng; Chou, Qingchuan; Ding, Qi; Su, Yuqing; Su, Haojie; Jeppesen, Erik; Wang, Liqing; Zhang, Wei (2025-08-01) Sediment properties have a crucial effect on the growth and recovery of aquatic plants in lakes. Addition of various chemical substances has been proposed to reinforce the recovery of plants after a nutrient loading reduct...
Performance of qpAdm-based screens for genetic admixture on graph-shaped histories and stepping stone landscapes Flegontova, Olga; Işlldak, Ulaş; Yüncü, Eren; Williams, Matthew P.; Huber, Christian D.; Kočí, Jan; Vyazov, Leonid A.; Changmai, Piya; Flegontov, Pavel (2025-05-01) qpAdm is a statistical tool that is often used for testing large sets of alternative admixture models for a target population. Despite its popularity, qpAdm remains untested on 2D stepping stone landscapes and in situation...
High nuclear genetic diversity of Birecik semi-wild population of endangered Bald Ibis<i> (Geronticus</i><i> eremita)</i> from Turkey Cakmak, Emel; Peksen, Cigdem Akan; Boran, Beril; Hatipo, Taner; Bilgin, Cemal Can (2025-05-01) The Northern Bald Ibis (Geronticus eremita) is an endangered species. The western population is estimated to be approximately 700 individuals, located in the Souss Massa region of Morocco. In contrast, the eastern populati...
Response of the submerged macrophyte Stuckenia pectinata (L.) Börner to warming in different climate regions: A synchronized oligohaline mesocosm experiment Billah, Md Masum; Yılmaz, Gültekin; Alves Amorım, Cıhelıo; Kuyumcu, Meltem; Arıkan, Onat; KORKMAZ, MUSTAFA; Arık, İrem Gamze; Beklioğlu, Meryem; Jeppesen, Erik; Özkan, Korhan (2025-05-01) Submerged macrophytes play a crucial role as primary producers and contribute essential ecosystem functions and services, but rising temperatures caused by climate change may alter their functional traits. We aimed to asse...
Environmental controls on the conversion of nutrients to chlorophyll in lakes Naderian, Danial; Noori, Roohollah; Kim, Dongkyun; Jun, Changhyun; Bateni, Sayed M.; Woolway, R. Iestyn; Sharma, Sapna; Shi, Kun; Qin, Boqiang; Zhang, Yunlin; Jeppesen, Erik; Maberly, Stephen C. (2025-04-15) Anthropogenic inputs of nitrogen and phosphorus to lakes have increased worldwide, causing phytoplankton chlorophyll concentrations to increase at many sites, with negative implications for biodiversity and human usage of ...
Influences of dissolved organic matter on phytoplankton functional diversity and resource use efficiency differ in three lakes with contrasting trophic state and depth Yu, Zhirong; Song, Di; Li, Jingyi; Zhang, Hucai; Qin, Jiang; Song, Lirong; Jeppesen, Erik; Zhou, Qichao (2025-04-01) Dissolved organic matter (DOM) plays a crucial role in both the penetration of light underwater and the biogeochemical cycles of carbon and nutrients in lakes, thereby largely influencing phytoplankton community structure ...
Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine Mohammed, Sawsan G. A. A.; Qoronfleh, M. Walid; Acar, Ahmet; Al-Dewik, Nader I. (2025-04-01) A “quiet revolution” in medicine has been taking place over the past two decades. There are two converging dynamic forces that have propelled precision medicine to the limelight, garnering wide public attention. The first ...
Inflow-modulated inputs of dissolved organic matter fuel carbon dioxide emissions from a large hyper-eutrophic lake Qian, Mingrui; Zhou, Yongqiang; Zhou, Lei; Zhang, Yunlin; Pu, Yang; Drake, Travis W.; Davidson, Thomas A.; Spencer, Robert G.M.; Brookes, Justin D.; Jeppesen, Erik (2025-04-01) Terrestrial dissolved organic matter (DOM) is potentially reactive and, upon entering lake ecosystems, can be readily degraded to low-molecular-weight organic matter and dissolved CO2. However, to date, there has been limi...
Restoring turbid eutrophic shallow lakes to a clear-water state by combined biomanipulation and chemical treatment: A 4-hectare in-situ experiment in subtropical China Li, Bo; Chen, Deyuan; Lu, Jichong; Liu, Suxia; Wu, Jiale; Gan, Lei; Yang, Xiaoqin; He, Xiaolin; He, Hu; Yu, Jinlei; Zhong, Ping; Tang, Yali; Zhang, Xiufeng; Du, Yingxun; Su, Yaling; Guan, Baohua; Chen, Feizhou; Li, Kuanyi; Jeppesen, Erik; Liu, Zhengwen (2025-04-01) While biomanipulation and chemical treatments have been applied to speed up the recovery of shallow eutrophic lakes through top-down and bottom-up effects, the efficacy of a combined approach has received less attention. W...
Prokaryotic and eukaryotic periphyton responses to warming, nutrient enrichment and small omnivorous fish: A shallow lake mesocosms experiment Yang, Han; Cao, Yu; Zhang, Wei; Pacheco, Juan Pablo; Liu, Tong; Zheng, Yaqi; Jeppesen, Erik; Wang, Liqing (2025-03-15) Global change stressors, including climate warming, eutrophication, and small-sized omnivorous fish, may exert interactive effects on the food webs and functioning of shallow lakes. Periphyton plays a central role in the p...
Benchmarking long-read structural variant calling tools and combinations for detecting somatic variants in cancer genomes. Aydin, Safa Kerem; Yilmaz, Kubra Celikbas; Acar, Ahmet (2025-03-13)
Leaf metabolomic traits decipher the invasiveness of Alternanthera philoxeroides in urban wetlands Huang, Xiaolong; Yang, Jinming; Yang, Xue; Wang, Tong; Meng, Jie; Guo, Xiao; Wang, Yang; Xiong, Wen; Zeng, Jin; Wu, Zhaoshi; Li, Kuanyi; Jeppesen, Erik (2025-03-10) Urbanisation has been considered to promote exotic plant invasion. Ecophysiology predicts phenotypic variation and potential evolution following urbanisation and can be used to evaluate plant invasiveness. However, few stu...
A phase I/II study of CpG/alum-adjuvanted mammalian-derived quadruple antigen carrying virus-like particle COVID-19 vaccine Yilmaz, Ismail Cem; İpekoğlu, Emre Mert; Golcuklu, Berfu Saraydar; Bildik, Tugce; Aksoy, Aslı Gulce Bartan; Evcili, Irem; Turay, Nilsu; Surucu, Naz; Bulbul, Artun; Guvencli, Nese; Yildirim, Muzaffer; Canavar Yildirim, Tugce; Atalay, Yagmur Aydin; Abras, Irem; Ceylan, Yasemin; Ozsurekci, Yasemin; Tigen, Elif Tukenmez; Korten, Volkan; Gürsel, Mayda; Gursel, Ihsan (2025-03-07) Background: Waning Spike-elicited immunity and emerging COVID-19 variants underscore the need for vaccines leveraging multiple SARS-CoV-2 antigens, rapidly adaptable to evolving strains. Herein, we evaluated the safety and...
A Preliminary and Multidisciplinary Study: The Effect of “Sleeping on The Beehives” and Listening to Bees on Human Anxiety Levels Tandırcıoğlu , Yankı; Acıkan , Hakan Burak; Bilgin, Cemal Can (2025-03-01) Apihouses are specialized wooden sheds designed to promote relaxation through sensory experiences associated with beehives, such as buzzing sounds and hive air, without direct interaction with bees. While anecdotal e...
Lateglacial and Holocene hydroclimatic variability documented by Cladocera of Tolbo Lake in the Altai Mountains, western Mongolia Li, Yuan; Liu, Xingxing; Wang, Wenjia; Xiang, Lixiong; Hu, Yu; Jeppesen, Erik; Demberel, Otgonbayar; Zolbayar, Jargalsaikhan; Huang, Xiaozhong (2025-03-01) The Altai Mountains contain rivers, lakes, and glaciers critical for the survival of both social and ecological systems. Reconstructing past hydroclimatic changes is crucial for understanding human-environment interactions...
“A Network of Mutualities of Being”: Socio-material Archaeological Networks and Biological Ties at Çatalhöyük Mazzucato, Camilla; Coscia, Michele; Küçükakdağ Doğu, Ayça; Haddow, Scott; Kılıç, Muhammed Sıddık; YÜNCÜ, EREN; Somel, Mehmet (2025-03-01) Recent advances in archaeogenomics have granted access to previously unavailable biological information with the potential to further our understanding of past social dynamics at a range of scales. However, to properly int...
A reappraisal of cell cycle phase enrichment in synchronized estrogen receptor-positive cell models derived from breast adenocarcinomas Toker, Pelin; Ayten, Hazal; Demiralay, Öykü Deniz; Bınarcı, Büşra; Turan, Gizem; Olgun, Çağla Ece; Yaşar, Pelin; Akman, Hesna Begüm; Muyan, Mesut (2025-02-18) 17β-estradiol (E2), the main circulating estrogen hormone, is a critical signaling factor for the growth, differentiation, and function of breast epithelial cells. The effects of E2 on the breast tissue are primarily media...
Dissolved organic carbon can alter coastal sediment phosphorus dynamic: Effects of different carbon forms and concentrations Ma, Shuo-Nan; Dong, Xu-Meng; Xu, Ji-Lin; Zhao, Chun-Pu; Liu, Miao; Wang, Hai-Jun; Jeppesen, Erik (2025-02-01) Coastal waters are receiving increasing loads of dissolved organic carbon (DOC), differing in structural complexity and molecular weights with potential different effects on the phosphorus (P) dynamics in these waters. Thi...

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