Application of Ultrasonic Waves in Bioparticle Manipulation and Separation

Date

2023-11-01

Author

Özer, Mehmet Bülent

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Acoustic technologies have played an increasingly significant role in both biologyand medicine, empowering scientists and clinicians to explore and understand theintricate workings of living organisms and develop innovative diagnostic and therapeuticapproaches. From ultrasound imaging to acoustic tweezers, from acousticbiosensors to acoustic stimulation, acoustic technologies have become indispensabletools in the arsenal of researchers and practitioners in these fields.Acoustic Technologies in Biology and Medicine is designed to be a cornerstonereference bridging the rapidly advancing acoustic technologies with state-of-the-artapplications in biology and medicine. The research in acoustics for biology andmedicine requires a multidisciplinary approach involving fluid mechanics, physics,chemistry, electronics, and the life sciences. The burgeoning success and eminenceof this field is fueled by the realization of groundbreaking technological innovationsand impactful solutions addressing significant biological problems. Thus, it isimperative to present this field to a diverse audience spanning multiple engineeringdisciplines and the life sciences, targeting their involvement and education on thebasic principles, breadth of technologies, and interdisciplinary applications of theacoustics. In this respect, Acoustic Technologies in Biology and Medicine adopts aunique role and context to introduce the graduate students and professionals froma broad range of backgrounds to this active research field, aiming to increase thesynergy and interaction between the engineers and life scientists.The book takes an interdisciplinary approach by covering the mechanistic andphysical basics, as well as the applications. First, the book covers the underlyingphysical and theoretical principles of acoustic technologies. This aims to help thereader grasp the fundamental principles of acoustics. Second, different technologiesof acoustic systems, including bulk and surface acoustic wave-based platforms,acoustic imaging, acoustic sensors, and acoustic levitators, are discussed. A clearunderstanding of the principles, advantages, and disadvantages of different acoustictechnologies is crucial for evaluating and determining which acoustic methods aremost suitable for particular biological applications. Third, state-of-the-art applicationsof acoustics in biology andmedicine are presented. These applications includesingle cell and organism manipulation, acoustic biosensing, cancer cell isolation(liquid biopsy), cell/tissue stimulation and ablation,micro-robot actuation, acousticimaging, and drug delivery.The book is intended for a broad audience, including researchers and studentsin physics, biology, and engineering, as well as clinicians and practitioners inmedicine. It is our hope that this book will provide a useful reference and inspirefurther research and innovation in the exciting and rapidly evolving field of acoustictechnologies in biology and medicine.

URI

https://onlinelibrary.wiley.com/doi/book/10.1002/9783527841325
https://hdl.handle.net/11511/106906

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Department of Mechanical Engineering, Book / Book chapter