Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
A Novel Methodology for the Asymmetric Synthesis of 2,3,5-Trisubstituted Piperazine Derivatives
Date
2024-01-01
Author
Beksultanova, Nurzhan
Özdemir, Özlem
Çaklr, Sldlka Polat
AYGÜN, MUHİTTİN
Doğan, Özdemir
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
76
views
0
downloads
Cite This
Piperazines constitute an important structural feature of many pharmaceuticals. For the discovery of new drugs, the ability to modify the lead compound s structure is crucial. Herein, we provide an efficient method for the synthesis of chiral 2,3,5-trisubstituted piperazine structures. Our route enables the synthesis of several novel chiral aryl aziridinyl ketones that could be converted into aziridine-fused bicyclic imines. The reduction of these imines and the nucleophilic ringopening reaction of the aziridine ring allowed us to synthesize highly functionalized piperazine derivatives.
Subject Keywords
asymmetric synthesis
,
aziridines
,
intramolecular cyclization
,
piperazines
,
Staudinger reaction
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85190724905&origin=inward
https://hdl.handle.net/11511/109588
Journal
Synthesis (Germany)
DOI
https://doi.org/10.1055/s-0040-1720114
Collections
Department of Business Administration, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
N. Beksultanova, Ö. Özdemir, S. P. Çaklr, M. AYGÜN, and Ö. Doğan, “A Novel Methodology for the Asymmetric Synthesis of 2,3,5-Trisubstituted Piperazine Derivatives,”
Synthesis (Germany)
, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85190724905&origin=inward.