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A Novel Methodology for the Asymmetric Synthesis of 2,3,5-Trisubstituted Piperazine Derivatives
Date
2024-01-01
Author
Beksultanova, Nurzhan
Özdemir, Özlem
Çaklr, Sldlka Polat
AYGÜN, MUHİTTİN
Doğan, Özdemir
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Piperazines constitute an important structural feature of many pharmaceuticals. For the discovery of new drugs, the ability to modify the lead compound s structure is crucial. Herein, we provide an efficient method for the synthesis of chiral 2,3,5-trisubstituted piperazine structures. Our route enables the synthesis of several novel chiral aryl aziridinyl ketones that could be converted into aziridine-fused bicyclic imines. The reduction of these imines and the nucleophilic ringopening reaction of the aziridine ring allowed us to synthesize highly functionalized piperazine derivatives.
Subject Keywords
asymmetric synthesis
,
aziridines
,
intramolecular cyclization
,
piperazines
,
Staudinger reaction
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85190724905&origin=inward
https://hdl.handle.net/11511/109588
Journal
Synthesis (Germany)
DOI
https://doi.org/10.1055/s-0040-1720114
Collections
Department of Business Administration, Article
Citation Formats
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BibTeX
N. Beksultanova, Ö. Özdemir, S. P. Çaklr, M. AYGÜN, and Ö. Doğan, “A Novel Methodology for the Asymmetric Synthesis of 2,3,5-Trisubstituted Piperazine Derivatives,”
Synthesis (Germany)
, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85190724905&origin=inward.