Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Stimuli-Responsive Nanoplatforms: ZIF-8-Decorated Ferrocenyl Surfactant-Based Vesicles for Synergistic Therapeutic Applications
Download
Adv Materials Inter - 2024 - Uysal - Stimuli‐Responsive Nanoplatforms ZIF‐8‐Decorated Ferrocenyl Surfactant‐Based Vesicles.pdf
Date
2024-01-01
Author
Uysal, Emin
Yavas, Sabiha Gulce
KALAYCIOĞLU, GÖKÇE DİCLE
POLAT, MUSTAFA
Kalıpçılar, Halil
AYDOĞAN, NİHAL
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
33
views
10
downloads
Cite This
One of the most important issues in the design and preparation of drug delivery systems in the recent years is versatility which includes providing synergistic therapeutic effects and sustainability. This study uses a redox-active ferrocenyl surfactant (FcN+(CH2CH3)3(CH2)10CH3, Fc(C11) where Fc is ferrocene) and pH responsive Zeolitic Imidazolate Framework-8 (ZIF-8) structures to form multifunctional assemblies (Fc(C11)-AOT/Rhb@ZIF-8/PDA) that can be used in several application including the drug delivery. The vesicles prepared using AOT-FC(C11) constitute the core of the structure. Since the location of the ferrocene group in the molecule structure, which is next to head group, the surface of the vesicles is decorated with the ferrocene group which can act as a Fenton reaction catalyst. The polydopamine (PDA) covered ZIF-8 are used to decorate the surface of the vesicles, creating a truly remarkable structure. The porous structure of ZIF-8 as well as the core of the vesicles can accommodate drug molecules. With the added NIR-responsive character upon PDA coating, this assembled structure can be used for phototermal therapy applications. The properties of this designed multifunctional and multi-responsive system are studied at different pH and under NIR-laser irradiation and show that it has potential to display a triple chemodynamic/ photothermal/ chemotherapeutic effect.
Subject Keywords
drug delivery systems
,
fenton reactions
,
synergistic therapy
,
vesicle
,
zeolitic imidazolate framework-8
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85196503577&origin=inward
https://hdl.handle.net/11511/110214
Journal
Advanced Materials Interfaces
DOI
https://doi.org/10.1002/admi.202400169
Collections
Department of Chemical Engineering, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
E. Uysal, S. G. Yavas, G. D. KALAYCIOĞLU, M. POLAT, H. Kalıpçılar, and N. AYDOĞAN, “Stimuli-Responsive Nanoplatforms: ZIF-8-Decorated Ferrocenyl Surfactant-Based Vesicles for Synergistic Therapeutic Applications,”
Advanced Materials Interfaces
, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85196503577&origin=inward.