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Improved brain effective connectivity modelling by dynamic Bayesian networks
Date
2024-09-01
Author
Ulusoy, İlkay
Geduk, Salih
Metadata
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Background: If brain effective connectivity network modelling (ECN) could be accurately achieved, early diagnosis of neurodegenerative diseases would be possible. It has been observed in the literature that Dynamic Bayesian Network (DBN) based methods are more successful than others. However, DBNs have not been applied easily and tested much due to computational complexity problems in structure learning. New method: This study introduces an advanced method for modelling brain ECNs using improved discrete DBN (Improved- dDBN) which addresses the computational challenges previously limiting DBN application, offering solutions that enable accurate and fast structure modelling. Results: The practical data and prior sizes needed for the convergence to the globally correct network structure are proved to be much smaller than the theoretical ones using simulated dDBN data. Besides, Hill Climbing is shown to converge to the true structure at a reasonable iteration step size when the appropriate data and prior sizes are used. Finally, importance of data quantization methods are analysed. Comparison with existing methods: The Improved-dDBN method performs better and robust, when compared to the existing methods for realistic scenarios such as varying graph complexity, various input conditions, noise cases and non-stationary connections. The data used in these tests is the simulated fMRI BOLD time series proposed in the literature. Conclusions: Improved-dDBN is a good candidate to be used on real datasets to accelerate developments in brain ECN modelling and neuroscience. Appropriate data and prior sizes can be identified based on the approach proposed in this study for global and fast convergence.
Subject Keywords
Brain effective connectivity modelling
,
Brain effective connectivity network
,
Discrete dynamic bayesian networks
,
Dynamic bayesian networks
,
fMRI
,
Machine learning
,
Neuroimaging data
,
Neurosicence
,
Simulated fMRI BOLD data
,
Structure learning
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85198269055&origin=inward
https://hdl.handle.net/11511/110262
Journal
Journal of Neuroscience Methods
DOI
https://doi.org/10.1016/j.jneumeth.2024.110211
Collections
Department of Electrical and Electronics Engineering, Article
Citation Formats
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BibTeX
İ. Ulusoy and S. Geduk, “Improved brain effective connectivity modelling by dynamic Bayesian networks,”
Journal of Neuroscience Methods
, vol. 409, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85198269055&origin=inward.