Mayda Gürsel

E-mail

mgursel@metu.edu.tr

Department

Department of Biology

ORCID

0000-0003-0044-9054

Scopus Author ID

6701661028

A phase I/II study of CpG/alum-adjuvanted mammalian-derived quadruple antigen carrying virus-like particle COVID-19 vaccine Yilmaz, Ismail Cem; İpekoğlu, Emre Mert; Golcuklu, Berfu Saraydar; Bildik, Tugce; Aksoy, Aslı Gulce Bartan; Evcili, Irem; Turay, Nilsu; Surucu, Naz; Bulbul, Artun; Guvencli, Nese; Yildirim, Muzaffer; Canavar Yildirim, Tugce; Atalay, Yagmur Aydin; Abras, Irem; Ceylan, Yasemin; Ozsurekci, Yasemin; Tigen, Elif Tukenmez; Korten, Volkan; Gürsel, Mayda; Gursel, Ihsan (2025-03-07) Background: Waning Spike-elicited immunity and emerging COVID-19 variants underscore the need for vaccines leveraging multiple SARS-CoV-2 antigens, rapidly adaptable to evolving strains. Herein, we evaluated the safety and...
Ruxolitinib treatment ameliorates clinical, immunologic, and transcriptomic aberrations in patients with STAT3 gain-of-function disease Bayram Catak, Feyza; et. al. (2024-01-01) Background: Signal transducer and activator of transcription 3 (STAT3) gain-of-function (GOF) disease presents with lymphoproliferation, autoimmunity, and failure to thrive. Although Janus kinase inhibitors have alleviated...
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation Temizoz, Burcu; Shibahara, Takayuki; Hioki, Kou; Hayashi, Tomoya; Kobiyama, Kouji; Lee, Michelle Sue Jann; Surucu, Naz; Sag, Erdal; Kumanogoh, Atsushi; Yamamoto, Masahiro; Gürsel, Mayda; Ozen, Seza; Kuroda, Etsushi; Coban, Cevayir; Ishii, Ken J. (2024-01-01) 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached ...
DOCK8 deficiency with hypereosinophilia and the syndrome of inappropriate antidiuretic hormone secretion during herpes infection Yeşil, Ayşe Mete; Kayaoğlu, Başak; Gül, Ersin; Gönç, Nazlı; Özön, Alev; Tezcan, İlhan; Gürsel, Mayda; ÇAĞDAŞ AYVAZ, DENİZ NAZİRE (2023-01-01) Background. Hyperimmunoglobulin E syndrome (HIES) due to dedicator of cytokinesis8 (DOCK8) deficiency may present in infancy and childhood with different clinical features involving recurrent infections, allergic dysregula...
Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency Yilmaz, Naz Surucu; et. al. (2022-01-01) NF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caused by mutations in the IKBKG gene. Conventionally, patients are afflicted with life threatening recurrent microbial infect...
Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency Sefer, Asena Pinar; et. al. (2022-01-01) Purpose MALT1 deficiency is a combined immune deficiency characterized by recurrent infections, eczema, chronic diarrhea, and failure to thrive. Clinical and immunological characterizations of the disease have not been pre...
The silent and dangerous inequity around access to COVID-19 testing: A call to action Comment Batista, Carolina; et. al. (2022-01-01)
COVID-19 Vaccine Inequity: High time to calibrate the global moral compass Gürsel, Mayda (2021-12-01)
Achieving global equity for COVID-19 vaccines: Stronger international partnerships and greater advocacy and solidarity are needed Figueroa, J. Peter; et. al. (2021-09-01) Peter Figueroa and co-authors advocate for equity in the worldwide provision of COVID-19 vaccines.
Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic Hotez, Peter J.; et. al. (2021-09-01) A Lancet Commission for COVID-19 task force is shaping recommendations to achieve vaccine and therapeu-tics access, justice, and equity. This includes ensuring safety and effectiveness harmonized through robust sys-tems of...

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