Ayşe Elif Erson Bensan

Department of Biology
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An alternatively spliced PD-L1 isoform PD-L1∆3, and PD-L2 expression in breast cancers: implications for eligibility scoring and immunotherapy response.
Döken, Didem Naz; Özgül, İbrahim; Yilmazbilek, Irem; Yakicier, Mustafa Cengiz; Karaca, Ezgi; Erson Bensan, Ayşe Elif (2023-09-28)
Targeting PD-1/PD-L1 has shown substantial therapeutic response and unprecedented long-term durable responses in the clinic. However, several challenges persist, encompassing the prediction of treatment effectiveness...
Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A.
Cacioppo, Roberta; Akman, Hesna Begum; Tuncer, Taner; Erson Bensan, Ayşe Elif; Lindon, Catherine (2023-06-29)
EGFR endocytosis: more than meets the eye
Sapmaz, Aysegul; Erson Bensan, Ayşe Elif (2023-04-10)
Assessment of silicon, glass, FR4, PDMS and PMMA as a chip material for acoustic particle/cell manipulation in microfluidics
Açıkgöz, Hande N.; Karaman, Alara; Şahin, M. Akif; Çaylan, Ömer R.; Büke, Göknur C.; Yıldırım, Ender; Eroğlu, İrem C.; Erson Bensan, Ayşe Elif; Çetin, Barbaros; Özer, Mehmet Bülent (2023-03-01)
In the present study, the capabilities of different chip materials for acoustic particle manipulation have been assessed with the same microfluidic device architecture, under the same actuator and flow conditions. Silicon,...
Versatile RNA: overlooked gems of the transcriptome.
Erdem, Murat; Cicek, Mustafa; Erson Bensan, Ayşe Elif (2023-01-31)
The critical role of RNA, its use and targetability concerning different aspects of human health are gaining more attention because our understanding of the versatility of RNA has dramatically evolved over the last decades...
Identification of an mRNA isoform switch for HNRNPA1 in breast cancers.
Erdem, Murat; Ozgul, İbrahim; Dioken, Didem Naz; Gurcuoglu, Irmak; Guntekin Ergun, Sezen; Cetin-Atalay, Rengul; Can, Tolga; Erson Bensan, Ayşe Elif (2021-12-27)
Roles of HNRNPA1 are beginning to emerge in cancers; however, mechanisms causing deregulation of HNRNPA1 function remain elusive. Here, we describe an isoform switch between the 3′-UTR isoforms of HNRNPA1 in breast cancers...
A C-term truncated EIF2Bγ protein encoded by an intronically polyadenylated isoform introduces unfavorable EIF2Bγ-EIF2γ interactions
Circir, Ayca; Bicakci, Gozde Koksal; Savas, Busra; Doken, Didem Naz; Henden, Onur; Can, Tolga; Karaca, Ezgi; Erson Bensan, Ayşe Elif (2021-11-19)
Eukaryotic translation initiates upon recruitment of the EIF2-GTP·Met-tRNAi ternary complex (TC) to the ribosomes. EIF2 (α, β, γ subunits) is a GTPase. The GDP to GTP exchange within EIF2 is facilitated by the guanine nucl...
Öyken, Merve; Çırçır Hatıl, Ayça; Çiçek, Esra; Erson Bensan, Ayşe Elif (HİPOKRAT YAYINCILIK, 2021-11-01)
HNRNPA1 Isoform Switch in Breast Cancers
Erson Bensan, Ayşe Elif; Özgül, İbrahim; Erdem, Murat; Döken, Didem Naz (2021-11-01)
Roles of HNRNPA1 are beginning to emerge in cancers; however, mechanisms causing deregulation of HNRNPA1 function remain elusive. Here, we identify and characterize an isoform switch between the 3’-UTR isoforms of HNRNPA1....
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.
Cicek, Esra; Circir, Ayca; Oyken, Merve; Akbulut Caliskan, Ozge; Dioken, Didem Naz; Guntekin Ergun, Sezen; Cetin-Atalay, Rengul; Sapmaz, Aysegul; Ovaa, Huib; Sahin, Ozgur; Erson Bensan, Ayşe Elif (2021-10-30)
Epidermal growth factor receptor (EGFR) has critical roles in epithelial cell physiology. Over-expression and over-activation of EGFR have been implicated in diverse cancers, including triple-negative breast cancers (TNBCs...
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