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Esra Nalbat
E-mail
esra@metu.edu.tr
Department
ORCID
0000-0002-4051-9793
Scopus Author ID
57204015514
Web of Science Researcher ID
AAB-9228-2020
Publications
Theses Advised
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Projects
Vicinal Diaryl-Substituted Isoxazole and Pyrazole Derivatives with in Vitro Growth Inhibitory and in Vivo Antitumor Activity
Turanll, Sümeyye; Nalbat, Esra; LENGERLİ, DENİZ; İBİŞ, KÜBRA; Güntekin Ergün, Sezen; Akhan Güzelcan, Ece; Muyan, Mesut; Cetin-Atalay, Rengul; Çallşkan, Burcu; BANOĞLU, ERDEN (2022-10-18)
The vicinal diaryl heterocyclic framework has been widely used for the development of compounds with significant bioactivities. In this study, a series of diaryl heterocycles were designed and synthesized based on an in-ho...
Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma
Nalbat, Esra; Tunçbağ, Nurcan; Cetin-Atalay, Rengul (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10)
Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed cancer and a leading cause of death worldwide. The hyperactivated cell survival signaling pathways cause resistance to conventional chemotherapeutics so t...
In vitro validation of drug-target interactions revealed in silico by Comprehensive Resource of Biomedical Relations with Network Representations and Deep Learning (CROssBAR) in HCC
Nalbat, Esra; DOĞAN, TUNCA; Martin, Maria Jesus; Cetin-Atalay, Rengul; Atalay, Mehmet Volkan (2020-08-01)
Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles.
Unal, O; Akkoc, Y; Kocak, M; Nalbat, Esra; Dogan-Ekici, AI; Yagci, Acar; Gozuacik, D (2020-04-28)
Nanoparticle based gene delivery systems holds great promise. Superparamagnetic iron oxide nanoparticles (SPIONs) are being heavily investigated due to good biocompatibility and added diagnostic potential, rendering such n...
DEEPScreen: high performance drug-target interaction prediction with convolutional neural networks using 2-D structural compound representations
Rifaioğlu, Ahmet Süreyya; Nalbat, Esra; Atalay, Mehmet Volkan (2020-03-07)
The identification of physical interactions between drug candidate compounds and target biomolecules is an important process in drug discovery. Since conventional screening procedures are expensive and time consuming, comp...
Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents.
ÇALIŞKAN, BURCU; Nalbat, Esra; Ibis, Kubra; Guzelcan, Ece Akhan; Atalay, Rengül; BANOĞLU, ERDEN (2018-12-01)
In our endeavour towards the development of effective anticancer therapeutics, a novel series of isoxazole-piperazine hybrids were synthesized and evaluated for their cytotoxic activities against human liver (Huh7 and Mahl...
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