Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma

2022-10
Nalbat, Esra
Tunçbağ, Nurcan
Cetin-Atalay, Rengul
Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed cancer and a leading cause of death worldwide. The hyperactivated cell survival signaling pathways cause resistance to conventional chemotherapeutics so that targeted therapies could extend patient survival for only a few months. Furthermore, there are limited chemotherapeutics for HCC patients due to impaired liver functions. Thus, it is vital to determine repurposed drugs and drug combinations in HCC treatment.

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Citation Formats
E. Nalbat, N. Tunçbağ, and R. Cetin-Atalay, “Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma,” Erdemli, Mersin, TÜRKİYE, 2022, p. 3104, Accessed: 00, 2023. [Online]. Available: https://hibit2022.ims.metu.edu.tr.