Is Boric Acid Toxic to Reproduction in Humans? Assessment of the Animal Reproductive Toxicity Data and Epidemiological Study Results

Date

2016-01-01

Author

DUYDU, YALÇIN
Basaran, Nursen
ÜSTÜNDAĞ, AYLİN
AYDIN DİLSİZ, SEVTAP
ÜNDEĞER BUCURGAT, ÜLKÜ
Ataman, Osman Yavuz
AYDOS, KAAN
Duker, Yalcm
Ickstadt, Katja
Waltrup, Brita Schulze
Golka, Klaus
Bolt, Hermann Maximilian

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

38
views

0
downloads

Boric acid and sodium borates are classified as toxic to reproduction in the CLP Regulation under "Category 1B" with the hazard statement of "H360FD". This classification is based on the reprotoxic effects of boric acid and sodium borates in animal experiments at high doses. However, boron mediated reprotoxic effects have not been proven in epidemiological studies so far. The epidemiological study performed in Bandirma boric acid production plant is the most comprehensive published study in this field with 204 voluntarily participated male workers. Sperm quality parameters (sperm morphology, concentration and motility parameters), FSH, LH and testosterone levels were determined in all participated employees as the reproductive toxicity biomarkers of males. However, boron mediated unfavorable effects on reproduction in male workers have not been determined even in the workers under very high daily boron exposure (0.21 mg B/kg-bw/day) conditions. The NOAEL for rat reproductive toxicity is equivalent to a blood boron level of 2020 ng/g. This level is higher than the mean blood boron concentration (223.89 +/- 69.49 ng/g) of the high exposure group workers in Bandirma boric acid production plant (Turkey) by a factor of 9. Accordingly, classifying boric acid and sodium borates under "Category 1B" as "presumed reproductive human toxicant in the CLP regulation seems scientifically not reasonable. The results of the epidemiological studies (including the study performed in China) support for a down-classification of boric acid from the category 1B, H360FD to category 2, H361d, (suspected of damaging the unborn child).

Subject Keywords

Boron exposure, Developmental toxicity, Reproductive toxicity, Sperm quality parameters

URI

https://hdl.handle.net/11511/30106

Journal

CURRENT DRUG DELIVERY

DOI

https://doi.org/10.2174/1567201812666151029101514

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Reproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in BandA +/- rma, Turkey DUYDU, YALÇIN; Basaran, Nursen; ÜSTÜNDAĞ, AYLİN; AYDIN DİLSİZ, SEVTAP; ÜNDEĞER BUCURGAT, ÜLKÜ; Ataman, Osman Yavuz; AYDOS, KAAN; Duker, Yalcin; Ickstadt, Katja; Waltrup, Britta Schulze; Golka, Klaus; Bolt, Hermann M. (2011-06-01) Boric acid and sodium borates have been considered as being "toxic to reproduction and development", following results of animal studies with high doses. Experimentally, a NOAEL (no observed adverse effect level) of 17.5 mg B/kg-bw/day has been identified for the (male) reproductive effects of boron in a multigeneration study of rats, and a NOAEL for the developmental effects in rats was identified at 9.6 mg B/kg-bw/day. These values are being taken as the basis of current EU safety assessments. The present...
Temporal and Spatial Distributions of Bisphenol A in Marine and Freshwaters in Turkey Özhan, Koray (2019-02-01) Bisphenol A (BPA), a chemical component used in the manufacture of plastics, is commonly introduced to and detected in aquatic environments. This is the first study conducted to understand the distribution of BPA in the marine and freshwaters of Turkey. The purpose of this study is to report BPA concentrations measured from a time-series conducted in coastal waters of Erdemli and regional rivers located in the northeastern Mediterranean region. Furthermore, seawater samples obtained from other Turkish coast...
Fate and degradation kinetics of nonylphenol compounds in aerobic batch digesters Omeroglu, Seçil; Sanin, Faika Dilek (2014-11-01) Nonylphenol (NP) compounds are toxic and persistent chemicals that are not fully degraded either in natural or engineered systems. Current knowledge indicates that these compounds concentrate in sewage sludge. Therefore, investigating the degradation patterns and types of metabolites formed during sludge treatment are important for land application of sewage sludge. Unfortunately, the information on the fate of nonylphenol compounds in sludge treatment is very limited. This study aims to investigate the bio...
Is aceticlastic methanogen composition in full-scale anaerobic processes related to acetate utilization capacity? Yilmaz, Vedat; Ince-Yilmaz, Ebru; Yılmazel Tokel, Yasemin Dilşad; Duran, Metin (Springer Science and Business Media LLC, 2014-06-01) In this study, biomass samples were obtained from six municipal and nine industrial full-scale anaerobic processes to investigate whether the aceticlastic methanogen population composition is related to acetate utilization capacity and the nature of the wastewater treated, i.e. municipal sludge or industrial wastewater. Batch serum bottle tests were used to determine the specific acetate utilization rate (AUR), and a quantitative real-time polymerase chain reaction protocol was used to enumerate the acetate...
Modeling the effects of irrigation by contaminated groundwater Hatipoğlu, Yasin Güray; Kurt, Zöhre; Yılmaz, Koray Kamil; Department of Earth System Science (2018) Pump and fertilize, while removing nitrate the groundwater, can also reduce nitrate and pesticide requirement. In this study, we constructed groundwater models via HYDRUS 1D for one-hectare maize field in prevalent soils in Turkey and Eskişehir, Adana, Şanlıurfa, Düzce climates in Turkey, assessed the most likely promising conditions for pump and fertilize, and found that even in 50 mg/L nitrate concentrations, this process is beneficial, especially in Şanlıurfa similar climates (687 TL/year). Nitrogen leac...

Citation Formats

Y. DUYDU et al., “Is Boric Acid Toxic to Reproduction in Humans? Assessment of the Animal Reproductive Toxicity Data and Epidemiological Study Results,” CURRENT DRUG DELIVERY, pp. 324–329, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30106.