Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters

2015-09-01
Celen, Ilker
MÜEZZİNOĞLU, TALHA
Ataman, Osman Yavuz
BAKIRDERE, Sezgin
KORKMAZ, MEHMET
NESE, NALAN
Senol, Feriye
Lekili, Murat
Show full item record
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
170
views
0
downloads
In the present study, tissue samples of patients with cancerous and non-cancerous prostate were analyzed for their Se, Ni, and Ca contents. Possible relationship between Se, Ni, and Ca concentrations and some parameters including preoperative prostate-specific antigen (PSA) levels, histopathological neurovascular invasion, extra-capsular extension, seminal vesicle invasion, positive surgical margins, PSA relapse after radical prostatectomy, and total Gleason scores were obtained. Inductively coupled plasma (ICP) optical emission spectrometry and ICP-mass spectrometry instruments were used for the determination of analytes interested. All the system parameters in digestion and measurement steps were optimized to obtain efficient digestion and sensitive measurements. There was no statistically meaningful difference observed in the concentration of selenium in cancerous and benign prostatic tissues (p = 0.347) while nickel levels in cancerous tissues were observed as significantly lower than benign tissues (p < 0.001). In addition, calcium concentration in cancerous tissue samples were found to be statistically lower than those in benign tissues (p < 0.001) with mean values of 657 and 1,431 mg/kg, respectively.
Selenium, Nickel, Calcium, Prostate cancer
https://hdl.handle.net/11511/30336
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Graduate School of Natural and Applied Sciences, Article

Suggestions

Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells
Ibis, Kubra; Sinoplu, Esra; ÇALIŞKAN, BURCU; Kahraman, Deniz Cansen; Cetin-Atalay, Rengul; BANOĞLU, ERDEN (2021-10-01)
In our effort for the development of novel anticancer therapeutics, a series of isoxazole-piperazine analogues were prepared, and primarily screened for their antiproliferative potential against hepatocellular carcinoma (HCC; Huh7/Mahlavu) and breast (MCF-7) cancer cells. All compounds demonstrated potent to moderate cytotoxicity on all cell lines with IC50 values in the range of 0.09-11.7 mu M. Further biological studies with 6a and 13d in HCC cells have shown that both compounds induced G1 or G2/M arrests...
Tannic Acid Inhibits Proliferation, Migration, Invasion of Prostate Cancer and Modulates Drug Metabolizing and Antioxidant Enzymes
KARAKURT, SERDAR; Adalı, Orhan (2016-01-01)
The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug metabolizing and antioxidant enzymes. Characterization of TA was done by using FT-IR and NMR. TA dose dependently inhibited the proliferation of PC-3 and LNCaP cells with IC50 values 35.3 mu M and 29.1 mu M, respectively. Wound healing assay showed that TA significantly inhibited (92.7%) migration of...
Enantiomerically pure beta-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways
Chan, Mei-Ling; Yu, Chia-Chun; Hsu, Jui-Ling; Leu, Wohn-Jenn; Chan, She-Hung; Hsu, Lih-Ching; Liu, Shih-Ping; Ivantcova, Polina M.; Doğan, Özdemir; Braese, Stefan; KUDRYAVTSEV, Konstantin V; GUH, Jih Hwa (Impact Journals, LLC, 2017-11-14)
The use of peptides that target cancer cells and induce anticancer activities through various mechanisms is developing as a potential anticancer strategy. KUD983, an enantiomerically pure beta-dipeptide derivative, displays potent activity against hormone-refractory prostate cancer (HRPC) PC-3 and DU145 cells with submicromolar IC50. KUD983 induced G1 arrest of the cell cycle and subsequent apoptosis associated with down-regulation of several related proteins including cyclin D1, cyclin E and Cdk4, and the ...
Application of Dempster-Schafer Method in Family-Based Association Studies
Rajabli, Farid; Goktas, Unal; İnan, Gül (2013-07-01)
In experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has ...
Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine-(thio)urea hybrids as potential kinase inhibitors.
Ture, Asli; Kahraman, Deniz Cansen; Atalay, Rengül; Helvacioglu, Sinem; Charehsaz, Mohammad; KÜÇÜKGÜZEL, İLKAY (2019-02-01)
Thirty-two novel urea/thiourea compounds as potential kinase inhibitor were designed, synthesized and evaluated for their cytotoxic activity on breast (MCF7), colon (HCT116) and liver (Huh7) cancer cell lines. Compounds 10, 19 and 30 possessing anticancer activity with IC50 values of 0.9, 0.8 and 1.6 mu M respectively on Huh7 cells were selected for further studies. These hit compounds were tested against liver carcinoma panel. Real time cell electronic sensing assay was used to evaluate the effects of the ...
Citation Formats
I. Celen et al., “Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters,” ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, pp. 13070–13076, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30336.
METU IIS - Integrated Information Service open@metu.edu.tr