Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications

Date

2012-11-01

Author

Unsoy, Gozde
Yalcin, Serap
Khodadust, Rouhollah
GÜNDÜZ, GÜNGÖR
Gündüz, Ufuk

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

205
views

0
downloads

The chitosan-coated magnetic nanoparticles (CS MNPs) were in situ synthesized by cross-linking method. In this method; during the adsorption of cationic chitosan molecules onto the surface of anionic magnetic nanoparticles (MNPs) with electrostatic interactions, tripolyphosphate (TPP) is added for ionic cross-linking of the chitosan molecules with each other. The characterization of synthesized nanoparticles was performed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS/ESCA), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS), thermal gravimetric analysis (TGA), and vibrating sample magnetometry (VSM) analyses. The XRD and XPS analyses proved that the synthesized iron oxide was magnetite (Fe3O4). The layer of chitosan on the magnetite surface was confirmed by FTIR. TEM results demonstrated a spherical morphology. In the synthesis, at higher NH4OH concentrations, smaller sized nanoparticles were obtained. The average diameters were generally between 2 and 8 nm for CS MNPs in TEM and between 58 and 103 nm in DLS. The average diameters of bare MNPs were found as around 18 nm both in TEM and DLS. TGA results indicated that the chitosan content of CS MNPs were between 15 and 23 % by weight. Bare and CS MNPs were superparamagnetic. These nanoparticles were found non-cytotoxic on cancer cell lines (SiHa, HeLa). The synthesized MNPs have many potential applications in biomedicine including targeted drug delivery, magnetic resonance imaging (MRI), and magnetic hyperthermia.

Subject Keywords

Magnetic Fe3o4-Chitosan nanoparticles, Drug-delivery, Superparamagnetic nanoparticles, Cross-linking, Particles, Diagnosis, Carriers

URI

https://hdl.handle.net/11511/30396

Journal

JOURNAL OF NANOPARTICLE RESEARCH

DOI

https://doi.org/10.1007/s11051-012-0964-8

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Synthesis, spectroscopic and electrochemical studies of perylene containing conjugated copolymers Bayseç, Şebnem; Toppare, Levent Kamil; Yılmaz, Levent; Department of Polymer Science and Technology (2013) The synthesis , spectroscopic and electrochemical properties of a series of donor-acceptor (DA) type polymers by changing the donor unit (thiophene, dithienopyrrole) polymer backbone were investigated.The synthesized CoP1 and CoP2 were designed to investigate the effect of copolymerization and insertion of perylene tetracarboxylic dimide (PDI) on the structure of benzotriazole (BTz) based polymers. For CoP1 1,7-dibromo-perylene diimide,4,7-dibromo-2-dodecyl-2H-benzo[d][1,2,3]triazole and 2,5 bis(tributylsta...
Synthesis, structural and magnetic characterization of soft magnetic nanocrystalline ternary FeNiCo particles Toparlı, Çiğdem; Gürmen, Sebahattin (2017-02-01) The present study focuses on the synthesis, microstructural and magnetic properties of ternary FeNiCo nanoparticles. Nanocrystalline ternary FeNiCo particles were synthesized via hydrogen reduction assisted ultrasonic spray pyrolysis method in single step. The effect of precursor concentration on the morphology and the size of particles was investigated. The syntheses were performed at 800 degrees C. Structure, morphology and magnetic properties of the as-prepared products were characterized through X-ray d...
Magnetic Fe3O4-chitosan micro- and nanoparticles for wastewater treatment ŞAHBAZ, DENİZ AKIN; YAKAR, ARZU; Gündüz, Ufuk (2019-08-18) In this study, first, magnetic nanoparticles (MNP) were synthesized using a coprecipitation method and the synthesized particles were characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), and vibrating sample magnetometry (VSM). According to DLS and VSM analyses results, it was seen that the size of the MNP was smaller than 10 nm and they exhibited superparamagnetic properties, respectively. Then, magnetic Fe3O4-chitosan micro/n...
Realization of magnetic resonance current density imaging at 3 Tesla, Göksu, Cihan; SADIGHI, MEHDI; Eyüboğlu, Behçet Murat (2014-08-26) Magnetic Resonance Current Density Imaging (MRCDI) is an imaging modality, which reconstructs electrical current density distribution inside a material by using Magnetic Resonance Imaging (MRI) techniques. In this study, a current source with maximum current injection capability of 224.7mA, under 1k Omega resistive load is used. Experiments are performed with a 2D uniform phantom, in which a current steering insulator is inserted. Magnetic flux density distributions are measured, and current density images ...
Synthesis, characterization and photovoltaic properties of benzo[c][1,2,5]oxadiazole based conjugated polymers for organic solar cells Karakurt, Oğuzhan; Çırpan, Ali; Günbaş, Emrullah Görkem; Department of Chemistry (2021-1-22) In this thesis, six conjugated polymers were synthesized by coupling of 2,1,3- benzoxadiazole derivatives with donor groups via Stille polycondensation reactions. Moreover, the effect of molecular weight for P1 and P2, effect of position of alkyl chain for P5 and effect of π-bridge groups for P6 which are selenophene and thiophene on optical, electrochemical, and photovoltaic properties were investigated. Also, modifications on alkyl chains of P3 and P4 were performed to increase their functionalities via p...

Citation Formats

G. Unsoy, S. Yalcin, R. Khodadust, G. GÜNDÜZ, and U. Gündüz, “Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications,” JOURNAL OF NANOPARTICLE RESEARCH, pp. 0–0, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30396.