Habibe Cansu Demirel

Graduate School of Informatics
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Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome
Yavuz, Bengi Ruken; Arici, M. Kaan; Demirel, Habibe Cansu; Tsai, Chung-Jung; Jang, Hyunbum; Nussinov, Ruth; Tunçbağ, Nurcan (2023-12-01)
Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs) are more prone to develop certain types of cancer. Notably, however, the case statistics can be impacted by late discovery of cancer...
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK
Nussinov, Ruth; Yavuz, Bengi Ruken; Arici, M Kaan; Demirel, Habibe Cansu; Zhang, Mingzhen; Liu, Yonglan; Tsai, Chung-Jung; Jang, Hyunbum; Tunçbağ, Nurcan (2023-01-01)
Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and mutations. Their clinical symptoms are different. However, individuals with NDDs have higher probabilities of eventually developing cancer. Here,...
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
Degirmenci, Bahar; Dincer, Cansu; Demirel, Habibe Cansu; Berkova, Linda; Moor, Andreas E.; Kahraman, Abdullah; Hausmann, George; Aguet, Michel; Tunçbağ, Nurcan; Valenta, Tomas; Basler, Konrad (2021-12-01)
Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that un...
Computational approaches leveraging integrated connections of multi-omic data toward clinical applications
Demirel, Habibe Cansu; Tunçbağ, Nurcan (2021-10-01)
In line with the advances in high-throughput technologies, multiple omic datasets have accumulated to study biological systems and diseases coherently. No single omics data type is capable of fully representing cellular ac...
Modeling the tumor specific structural networks by integrating alternative splicing events
Demirel, Habibe Cansu; Tunçbağ, Nurcan (null; 2018-09-08)
The Effect of Alternative Splicing on Tumor Specific Protein Networks
Demirel, Habibe Cansu; Tunçbağ, Nurcan (2017-06-28)
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