Habibe Cansu Demirel

E-mail

cansud@metu.edu.tr

Department

Graduate School of Informatics

ORCID

0000-0002-4874-2308

Scopus Author ID

57203318771

Web of Science Researcher ID

ABA-3498-2020

Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide Nussinov, Ruth; Yavuz, Bengi Ruken; Demirel, Habibe Cansu; Arici, M. Kaan; Jang, Hyunbum; Tunçbağ, Nurcan (2024-01-01) The connection and causality between cancer and neurodevelopmental disorders have been puzzling. How can the same cellular pathways, proteins, and mutations lead to pathologies with vastly different clinical presentations?...
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome Yavuz, Bengi Ruken; Arici, M. Kaan; Demirel, Habibe Cansu; Tsai, Chung-Jung; Jang, Hyunbum; Nussinov, Ruth; Tunçbağ, Nurcan (2023-12-01) Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs) are more prone to develop certain types of cancer. Notably, however, the case statistics can be impacted by late discovery of cancer...
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK Nussinov, Ruth; Yavuz, Bengi Ruken; Arici, M Kaan; Demirel, Habibe Cansu; Zhang, Mingzhen; Liu, Yonglan; Tsai, Chung-Jung; Jang, Hyunbum; Tunçbağ, Nurcan (2023-01-01) Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and mutations. Their clinical symptoms are different. However, individuals with NDDs have higher probabilities of eventually developing cancer. Here,...
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model Degirmenci, Bahar; Dincer, Cansu; Demirel, Habibe Cansu; Berkova, Linda; Moor, Andreas E.; Kahraman, Abdullah; Hausmann, George; Aguet, Michel; Tunçbağ, Nurcan; Valenta, Tomas; Basler, Konrad (2021-12-01) Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that un...
Computational approaches leveraging integrated connections of multi-omic data toward clinical applications Demirel, Habibe Cansu; Tunçbağ, Nurcan (2021-10-01) In line with the advances in high-throughput technologies, multiple omic datasets have accumulated to study biological systems and diseases coherently. No single omics data type is capable of fully representing cellular ac...
Modeling the tumor specific structural networks by integrating alternative splicing events Demirel, Habibe Cansu; Tunçbağ, Nurcan (null; 2018-09-08)
The Effect of Alternative Splicing on Tumor Specific Protein Networks Demirel, Habibe Cansu; Tunçbağ, Nurcan (2017-06-28)

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