Synthesis and surface modification of polyurethanes with chitosan for antibacterial properties

Date

2014-11-04

Author

Kara, Filiz
AKSOY, EDA AYŞE
YÜKSEKDAĞ, ZEHRANUR
Hasırcı, Nesrin
AKSOY, SERPİL

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Surface modification and providing antibacterial properties to the materials or devices are getting great attention especially in the last decades. In this study, polyurethane (PU) films were prepared by synthesizing them in medical purity from toluene diisocyanate and polypropylene ethylene glycol without using any other ingredients and then the film surfaces were modified by covalent immobilization of chitosan (CH) which has antibacterial activity. CH immobilized PU films (PU-CH) were found to be more hydrophilic than control PU films. Electron Spectroscopy for Chemical Analysis (ESCA) and Atomic Force Microscopy (AFM) analyses showed higher nitrogen contents and rougher surface topography for PU-CH compared to PU films. Modification with CH significantly increased antibacterial activity against Gram positive (Staphylococcus aureus) and Gram negative (Pseudomonas aeruginosa) bacteria. It was observed that the number of bacteria colonies were less about 10(2)-10(5) CFU/mL and number of attached viable bacteria decreased significantly after CH modification of PU films.

Subject Keywords

Polyurethane, Chitosan, Surface modification, Antibacterial, Bacterial adhesion

URI

https://hdl.handle.net/11511/31502

Collections

Graduate School of Natural and Applied Sciences, Article