Targeted silencing of Survivin in cancer cells by siRNA loaded chitosan magnetic nanoparticles

Gündüz, Ufuk
Background: The aim of this study was to silence Survivin expression, related with drug-resistance, via siRNA-loaded CS-MNPs.


Timing observations from Rossi X-ray Timing Explorer (RXTE)
Beklen, Elif; Baykal, Altan; Department of Physics (2004)
In this thesis, RXTE observations of 4U 1907+09 are presented. Timing analysis of these data sets have yielded quasi periodic oscillations (QPOs) at orbital phases corresponding to the two flares in every orbital period. Known continuous spin down trend and QPO behaviour at the flares strongly suggest that a transient accretion disk occurs at the flares. Our findings strongly suggested that neutron star passes through the equatorial wind of Be companion star. During these passages a transient disk forms aro...
Influences of halloysite nanotubes on crystallisation behaviour of polylactide
Kaygusuz, I.; Kaynak, Cevdet (2015-03-01)
The aim of this study was to investigate influences of halloysite nanotubes (HNTs) on the (i) isothermal and (ii) non-isothermal crystallisation kinetics of polylactide (PLA) by differential scanning calorimetry (DSC) analyses, and (iii) crystallinity of injection moulded and then annealed specimens by DSC and X-ray diffraction (XRD) analyses. Nanocomposites were compounded using melt mixing technique via twin screw extrusion. Owing to basically very effective heterogeneous nucleation effect, addition of HN...
Utilization of Scytalidium thermophilum phenol oxidase in bioorganic synthesis
Kaptan, Yelda; Ögel, Zümrüt Begüm; Department of Biotechnology (2004)
In this study, the ultimate aim was to utilize phenol oxidases of Scytalidium thermophilum in bioorganic syntheses. For this purpose, studies were conducted towards enhancing the production of phenol oxidases by Scytalidium thermophilum, developing a suitable method for laccase activity assays, analyzing the effects of organic solvents on phenol oxidase activity and analysis of the biotransformation of a number of organic substrates by phenol oxidases of Scytalidium thermophilum. In order to enhance the pro...
Evaluating an Immersive Virtual Learning Environment for Learning How to Design in Human-Scale
Sonmez, Orkun; Sorguç, Arzu (2018-01-01)
This paper presents a part of a thesis research conducted at METU. It proposes a method for evaluating the effects of an immersive virtual learning environment (IVLE) which is integrated in an architectural design/learning activity. Proposed IVLE application and design/learning activity were designed through a synthesis on constructive learning, problem-based learning, immersive technologies, and intended learning outcomes (ILOs) in learning how to design in human-scale. Immersive experience of bodily inter...
Alternative Assessment as a Motivational Tool for Young Learners
Çetin, Lynn Bethard; Gürbüz, Nurdan (2015-05-10)
This paper is conducted to highlight the motivational role of alternative assessment in the teaching/learning of English for specific purposes (ESP). The population is the students of Sudan International University (SIU). Mixed methods are adopted. The use of both thematic and statistical analysis techniques, has interpreted a significant encouraging correlation between students' final accomplishment and their achievement in in-class activities. Moreover, students...
Citation Formats
G. ÜNSOY and U. Gündüz, “Targeted silencing of Survivin in cancer cells by siRNA loaded chitosan magnetic nanoparticles,” EXPERT REVIEW OF ANTICANCER THERAPY, pp. 789–797, 2016, Accessed: 00, 2020. [Online]. Available: