Synthesis and Characterization of Polyhydroxybutyrate Coated Magnetic Nanoparticles: Toxicity Analyses on Different Cell Lines

Date

2015-01-01

Author

Yalcin, Serap
Khodadust, Rouhollah
Unsoy, Gozde
Garip, Immihan Ceren
Mumcuoglu, Zahide Didem
Gündüz, Ufuk

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In this study, polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared which are targetable to tumor cells in the presence of a magnetic field. The structural properties, functional groups, size distribution, and magnetic properties of the synthesized PHB coated magnetic nanoparticles were characterized by X-ray diffraction, Fourier transform infrared spectrometer, transmission electron microscopy, dynamic light scattering, vibrating sample magnetometry, and thermogravimetric analysis. PHB coated nanoparticles are efficiently internalized by the cancer cells in culture, without cytotoxicity. The results demonstrated that PHB coated iron oxide nanoparticles are suitable for targeted delivery of drugs such as chemotherapeutics, siRNA, miRNA, or antibodies.

Subject Keywords

Polyhydroxybutyrate, Genotoxicity, Cytotoxicity, Magnetic nanoparticle, Anticancer agents

URI

https://hdl.handle.net/11511/32020

Journal

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY

DOI

https://doi.org/10.1080/15533174.2013.831448

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

S. Yalcin, R. Khodadust, G. Unsoy, I. C. Garip, Z. D. Mumcuoglu, and U. Gündüz, “Synthesis and Characterization of Polyhydroxybutyrate Coated Magnetic Nanoparticles: Toxicity Analyses on Different Cell Lines,” SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, pp. 700–708, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32020.