Bengi Ruken Yavuz

E-mail

bengiy@metu.edu.tr

Department

Graduate School of Informatics

ORCID

0000-0002-3472-8767

Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide Nussinov, Ruth; Yavuz, Bengi Ruken; Demirel, Habibe Cansu; Arici, M. Kaan; Jang, Hyunbum; Tunçbağ, Nurcan (2024-01-01) The connection and causality between cancer and neurodevelopmental disorders have been puzzling. How can the same cellular pathways, proteins, and mutations lead to pathologies with vastly different clinical presentations?...
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome Yavuz, Bengi Ruken; Arici, M. Kaan; Demirel, Habibe Cansu; Tsai, Chung-Jung; Jang, Hyunbum; Nussinov, Ruth; Tunçbağ, Nurcan (2023-12-01) Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs) are more prone to develop certain types of cancer. Notably, however, the case statistics can be impacted by late discovery of cancer...
Pan-cancer clinical impact of latent drivers from double mutations Yavuz, Bengi Ruken; Tsai, Chung-Jung; Nussinov, Ruth; Tuncbag, Nurcan (2023-12-01) Here, we discover potential ‘latent driver’ mutations in cancer genomes. Latent drivers have low frequencies and minor observable translational potential. As such, to date they have escaped identification. Their discovery ...
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK Nussinov, Ruth; Yavuz, Bengi Ruken; Arici, M Kaan; Demirel, Habibe Cansu; Zhang, Mingzhen; Liu, Yonglan; Tsai, Chung-Jung; Jang, Hyunbum; Tunçbağ, Nurcan (2023-01-01) Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and mutations. Their clinical symptoms are different. However, individuals with NDDs have higher probabilities of eventually developing cancer. Here,...
Mechanism of activation and the rewired network: New drug design concepts Nussinov, Ruth; Zhang, Mingzhen; Maloney, Ryan; Tsai, Chung-Jung; Yavuz, Bengi Ruken; Tunçbağ, Nurcan; Jang, Hyunbum (2021-10-01) Precision oncology benefits from effective early phase drug discovery decisions. Recently, drugging inactive protein conformations has shown impressive successes, raising the cardinal questions of which targets can profit ...