Partially Observable Gene Regulatory Network Control Without a Boundary on Horizon

Date

2012-11-09

Author

Erdogdu, Utku
Polat, Faruk
Alhajj, Reda

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Gene regulatory networks (GRNs) govern the protein transcription process in the cell and interactions among genes play a vital role in determining the biosynthesis rate of proteins. By using intervention techniques discovered by biological research it is possible to control a GRN, thus promoting or demoting the expression rate of a certain gene. In this work, this control task is studied in a partially observable setting where interventions lack perfect knowledge of the expression level of all genes. Moreover, we formulated the task as a lifelong control problem and developed a more flexible and scalable method than the alternatives described in the literature.

Subject Keywords

POMDP, Gene regulatory network, Gene expression data, GRN control

URI

https://hdl.handle.net/11511/35611

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Department of Computer Engineering, Conference / Seminar