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A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds
Date
1996-01-15
Author
Demir, AS
Tanyeli, Cihangir
Sesenoglu, O
Demic, S
Evin, OO
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroxyiminophosphonates with NaBH4 in MeOH in the presence of MoO3 or NiCl2 and hydrolysis of 1- aminophosphonates gave 1-aminophosphonic acids in good yield.
Subject Keywords
Organic Phosphorus-Compounds
,
Sodium-Borohydride
,
Aminophosphonic Acids
,
Salt Systems
,
Derivatives
,
Reduction
,
Chloride
,
Hydrogenation
,
Inhibitors
URI
https://hdl.handle.net/11511/36580
Journal
TETRAHEDRON LETTERS
DOI
https://doi.org/10.1016/0040-4039(95)02171-x
Collections
Department of Chemistry, Article
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A. Demir, C. Tanyeli, O. Sesenoglu, S. Demic, and O. Evin, “A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds,”
TETRAHEDRON LETTERS
, pp. 407–410, 1996, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36580.