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Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

2017-01-01
GÜRDAL HAKGÖR, ENİSE ECE
Turgutalp, Bengisu
Gulcan, Hayrettin Ozan
Ercetin, Tugba
Şahin, Mustafa
Durmaz, Irem
Atalay, Rengül
Quoc Dat Nguyen, Quoc Dat Nguyen
Sippl, Wolfgang
YARIM YÜKSEL, MİNE
Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.