Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

2017-01-01
GÜRDAL HAKGÖR, ENİSE ECE
Turgutalp, Bengisu
Gulcan, Hayrettin Ozan
Ercetin, Tugba
Şahin, Mustafa
Durmaz, Irem
Atalay, Rengül
Quoc Dat Nguyen, Quoc Dat Nguyen
Sippl, Wolfgang
YARIM YÜKSEL, MİNE
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Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.
Acetylcholinesterase; benzothiazole; cytotoxicity; , Sulforhodamine B, Piperazine, Ellman's method, Ellman's method, Ellman's method, Ellman's method, Docking, Acetylcholinesterase, Cytotoxicity, Benzothiazole
https://hdl.handle.net/11511/37141
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Center for Wind Energy (RÜZGEM), Article

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Citation Formats
E. E. GÜRDAL HAKGÖR et al., “Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents,” ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, pp. 1837–1845, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37141.
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