Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

Turgutalp, Bengisu
Gulcan, Hayrettin Ozan
Ercetin, Tugba
Şahin, Mustafa
Durmaz, Irem
Atalay, Rengül
Quoc Dat Nguyen, Quoc Dat Nguyen
Sippl, Wolfgang
Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.


Synthesis and Cytotoxicity Studies on Novel Piperazinylacetamides
Bobtaina, Eman; GÜRDAL HAKGÖR, ENİSE ECE; Durmaz, Irem; Atalay, Rengül; YARIM YÜKSEL, MİNE (2019-01-01)
Background: In this study, nine novel compounds, bearing N-[2-(4-substituted piperazine-1-yl)acetyl]-N'-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized.
Synthesis and characterization of novel quinoxalinebased and thieno[3,4-c]pyrrole-4,6-dione-based conjugated polymers and their applications in organic electronics
Karabağ, Aliekber; Günbaş, Emrullah Görkem; Department of Polymer Science and Technology (2017)
In this thesis novel quinoxaline-based and thieno[3,4-c]pyrrole-4,6-dione (TPD)- based monomers were firstly synthesized. Structural analysis of each material synthesized was performed with Nuclear Magnetic Resonance (NMR) Spectroscopy and High-Resolution Mass Spectroscopy (HRMS). Two novel quinoxaline-based monomers were polymerized with electrochemical and/or chemical polymerization whereas TPD-based monomer was polymerized with benzodithiophene-based acceptor via Stille coupling polycondensation reaction...
Synthesis of conducting block copolymers and their use in the immobilization of invertase and polyphenol oxidase enzyme
Kıralp, Senem; Kıralp, Senem; Department of Chemistry (2004)
A new thiophene derivative containing menthyl group (MM) was synthesized and polymerized via chemical and electrochemical methods. Polymers obtained and MM itself were used to synthesize copolymers with pyrrole under conditions of constant potential electrolysis. Cyclic Voltammetry, thermal analysis and scanning electron microscopy analyses were performed for the characterization of samples. Immobilization of invertase and polyphenol oxidase enzymes was performed in the matrices obtained via copolymerizatio...
Synthesis and electrochromic properties of a multichromic, conducting, soluble polythiophene derivative and its copolymer
Özyurt, Funda; Toppare, Levent Kamil; Department of Chemistry (2009)
A new polythiophene derivative, poly-2,3-bis(4-tert-butylphenyl)-5,8-bis(4-hexylthiophen-2-yl)quinoxaline PHTQ was synthesized by both chemical and electrochemical polymerization and its electrochemical properties were reported. The monomer was electrochemically polymerized in the presence of tetrabutylammonium hexafluorophosphate(TBAPF6) as the supporting electrolyte in dichloromethane-acetonitrile (5:95, v:v). Nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR) was utilized for the characterization ...
Development of a new method for the synthesis of benzo[h][1,6]naphthyridine derivatives and chromenopyrazinone skeleton
Hoplamaz, Emre; Balcı, Metin; Department of Chemistry (2015)
In the first part of this thesis, a new methodology was developed for the synthesis of benzo[h][1,6]naphthyridine derivatives. Firstly, 2-(diprop-2-ynylamino)benzaldehyde was synthesized starting from 2-aminobenzoic acid in three steps. Then, cyclization reaction was achieved in the presence of propargyl amine and DBU. The expected 3-methylbenzo[h][1,6]naphthyridine was obtained. To generalize this methodology, several derivatives of 2-(diprop-2-ynylamino)benzaldehyde were synthesized by applying Sonogashir...
Citation Formats
E. E. GÜRDAL HAKGÖR et al., “Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents,” ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, pp. 1837–1845, 2017, Accessed: 00, 2020. [Online]. Available: