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Transcriptional neoteny in the human brain
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Date
2009-04-07
Author
Somel, Mehmet
Franz, Henriette
Yan, Zheng
Lorenc, Anna
Guo, Song
Giger, Thomas
Kelso, Janet
Nickel, Birgit
Dannemann, Michael
Bahn, Sabine
Webster, Maree J.
Weickert, Cynthia S.
Lachmann, Michael
Paeaebo, Svante
Khaitovich, Philipp
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits. We analyzed mRNA expression in the prefrontal cortex of humans, chimpanzees, and rhesus macaques to determine whether human-specific neotenic changes are present at the gene expression level. We show that the brain transcriptome is dramatically remodeled during postnatal development and that developmental changes in the human brain are indeed delayed relative to other primates. This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development.
Subject Keywords
Human evolution
,
Brain development
,
Gene expression
,
Heterochrony
,
Chimpanzee
URI
https://hdl.handle.net/11511/39657
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
DOI
https://doi.org/10.1073/pnas.0900544106
Collections
Department of Biology, Article