Phospholipid Complexation of General Anesthetics in Fluid Bilayers

Download
2010-04-20
Türkyılmaz, Serhan
Chen, Wen-Hua
Regen, Steven L.
A nearest-neighbor recogntion analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a funamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC Forms 1:1 complexes with CHCl3 in both membranes in the fluid bilayer state.
LANGMUIR

Suggestions

Encapsulated Hydrogels by E-beam Lithography and Their Use in Enzyme Cascade Reactions
Mancini, Rock J.; Paluck, Samantha J.; Bat, Erhan; Maynard, Heather D. (American Chemical Society (ACS), 2016-04-26)
Electron beam (e-beam) lithography was employed to prepare one protein immobilized hydrogel encapsulated inside another by first fabricating protein-reactive hydrogels of orthogonal reactivity and subsequently conjugating the biomolecules. Exposure of thin films of eight arm star poly(ethylene glycol) (PEG) functionalized with biotin (Biotin PEG), alkyne (Alkyne-PEG) or aminooxy (AO-PEG) end groups to e-beam radiation resulted in cross-linked hydrogels with the respective functionality. It was determined vi...
Liposomal Nanoreactors for the Synthesis of Monodisperse Palladium Nanoparticles Using Glycerol
Clergeaud, Gael; Genc, Rukan; Ortiz, Mayreli; O'Sullivan, Ciara K. (American Chemical Society (ACS), 2013-12-10)
The synthesis of highly stable ultrasmall monodisperse populations of palladium nanoparticles in the range of 1-3 nm in size was achieved via polyol reduction within 1,2-dioleoyl-sn-glycero-3-phosphor-rac(1-glycerol) liposomal nanoreactors exploiting glycerol as both reducing and stabilizing agent. The liposome-based green method was compared with synthesis in solution, and the reducing agent concentration and the lipidic composition of the liposomal nanoreactors were demonstrated to have a strong effect on...
Active Janus Particles at Interfaces of Liquid Crystals
Mangal, Rahul; Nayani, Karthik; Kim, Young-Ki; Büküşoğlu, Emre; Cordova-Figueroa, Ubaldo M.; Abbott, Nicholas. L. (American Chemical Society (ACS), 2017-10-17)
We report an investigation of the active motion of silica palladium Janus particles (JPs) adsorbed at interfaces formed between nematic liquid crystals (LCs) and aqueous phases containing hydrogen peroxide (H2O2). In comparison to isotropic oil aqueous interfaces, we observe the elasticity and anisotropic viscosity of the nematic phase to change qualitatively the active motion of the JPs at the LC interfaces. Although contact line pinning on the surface of the JPs is observed. to restrict out-of-plane rotat...
Synthesis of aromatic poly(pyridinium salt)s and their electrochromic properties
Keshtov, M. L.; UDUM, YASEMİN; Toppare, Levent Kamil; Kochurov, V. S.; Khokhlov, A. R. (Elsevier BV, 2013-05-15)
Synthesis of a series of new conjugated electrochromic polymeric pyridinium salts containing main-chain triphenylamine and their electrochromic properties were demonstrated. All polymers exhibit intense UV absorptions at 336-338 nm in DMF and 340-343 nm in thin film form and fluorescence centered at 410-438 nm in DMF and 460-461 nm in thin film form. The electrochromic properties of the films were investigated by electrochemical and spectroelectrochemical methods. Reversible redox signals with stable electr...
Design Parameters and Principles of Liquid-Crystal-Templated Synthesis of Polymeric Materials via Photolithography
AKDENİZ, BURAK; Büküşoğlu, Emre (American Chemical Society (ACS), 2019-10-08)
The design parameters and principles for the synthesis of polymeric microscopic objects using a method that combines photolithography and liquid crystal (LC) molecular templates have been demonstrated. Specifically, mixtures of a reactive mesogen (RM257) and nonreactive LC (E7) were polymerized using UV light and a photomask. We used photomasks with circular, triangular, rectangular, square, star-shaped, and heart-shaped features to provide initial shapes to the objects. Then, the unreacted parts were extra...
Citation Formats
S. Türkyılmaz, W.-H. Chen, and S. L. Regen, “Phospholipid Complexation of General Anesthetics in Fluid Bilayers,” LANGMUIR, pp. 5309–5311, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/39662.