Phospholipid Complexation of General Anesthetics in Fluid Bilayers

Date

2010-04-20

Author

Türkyılmaz, Serhan
Mitomo, Hideyuki
Chen, Wen-Hua
Regen, Steven L.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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A nearest-neighbor recogntion analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a funamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC Forms 1:1 complexes with CHCl3 in both membranes in the fluid bilayer state.

Subject Keywords

Spectroscopy, Electrochemistry, General Materials Science, Surfaces and Interfaces, Condensed Matter Physics

URI

https://hdl.handle.net/11511/39662

Collections

Department of Chemistry, Article