Phospholipid Complexation of General Anesthetics in Fluid Bilayers

Türkyılmaz, Serhan
Mitomo, Hideyuki
Chen, Wen-Hua
Regen, Steven L.
A nearest-neighbor recogntion analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a funamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC Forms 1:1 complexes with CHCl3 in both membranes in the fluid bilayer state.

Citation Formats
S. Türkyılmaz, H. Mitomo, W.-H. Chen, and S. L. Regen, “Phospholipid Complexation of General Anesthetics in Fluid Bilayers,” LANGMUIR, vol. 26, no. 8, pp. 5309–5311, 2010, Accessed: 00, 2020. [Online]. Available: