Phospholipid Complexation of General Anesthetics in Fluid Bilayers

Türkyılmaz, Serhan
Chen, Wen-Hua
Regen, Steven L.
A nearest-neighbor recogntion analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a funamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC Forms 1:1 complexes with CHCl3 in both membranes in the fluid bilayer state.


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Electron beam (e-beam) lithography was employed to prepare one protein immobilized hydrogel encapsulated inside another by first fabricating protein-reactive hydrogels of orthogonal reactivity and subsequently conjugating the biomolecules. Exposure of thin films of eight arm star poly(ethylene glycol) (PEG) functionalized with biotin (Biotin PEG), alkyne (Alkyne-PEG) or aminooxy (AO-PEG) end groups to e-beam radiation resulted in cross-linked hydrogels with the respective functionality. It was determined vi...
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The design parameters and principles for the synthesis of polymeric microscopic objects using a method that combines photolithography and liquid crystal (LC) molecular templates have been demonstrated. Specifically, mixtures of a reactive mesogen (RM257) and nonreactive LC (E7) were polymerized using UV light and a photomask. We used photomasks with circular, triangular, rectangular, square, star-shaped, and heart-shaped features to provide initial shapes to the objects. Then, the unreacted parts were extra...
Citation Formats
S. Türkyılmaz, W.-H. Chen, and S. L. Regen, “Phospholipid Complexation of General Anesthetics in Fluid Bilayers,” LANGMUIR, pp. 5309–5311, 2010, Accessed: 00, 2020. [Online]. Available: