Strontium and fluorine co-doped biphasic calcium phosphate: characterization and in vitro cytocompatibility analysis

Pourreza, Elmira
Yilmaz, Bengi
Rad, Reza Moonesi
Tezcaner, Ayşen
Evis, Zafer
Strontium (Sr2+) and fluoride (F-) ions are known to play an important role in bone and tooth metabolism. In this work, we prepare biphasic calcium phosphate (BCP) bioceramics co-doped with different fractions of Sr2+ and F- ions to investigate the impact of dopant on the crystal structure and biological properties of BCP bioceramics. The materials were successfully synthesized using a wet precipitation method, followed by sintering at 1100 degrees C for 1 h. The sintered materials were characterized using x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FESEM). XRD analysis revealed that the BCP bioceramics were composed of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP), along with calcium oxide (CaO) as impurity. Furthermore, the percentage of beta-TCP tended to increase with an increase in the Sr2+ ion concentration. The lattice parameters of HA phase expanded along with incorporation of Sr2+ and F- ions. The morphology of the yielding materials demonstrated that the incorporation of Sr2+ and F- ions caused a decrease in the grain size. The Vickers hardness (HV) test showed that hardness values increased with increasing Sr2+ concentrations. In vitro cell culture tests were performed with human osteogenic sarcoma (Saos-2) cell line. Saos-2 cells attached and proliferated faster on Sr/F-BCP materials compared to pure BCP, showing that Sr/F-BCP materials were cytocompatible.


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The purpose of this study was to synthesize calcium phosphates doped with titanium and fluoride ions in different combinations. Pure and doped calcium phosphates were synthesized by a precipitation method. The synthesized materials were sintered at 1100ºC and 1300ºC for 1h. The ceramics were characterized by density measurements to determine the effect of sintering temperature. Presence of phases and bonds were characterized by XRD diffraction and FTIR spectroscopy. Grain sizes of the samples were obtained ...
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Citation Formats
E. Pourreza, A. Z. G. ALSHEMARY, B. Yilmaz, R. M. Rad, A. Tezcaner, and Z. Evis, “Strontium and fluorine co-doped biphasic calcium phosphate: characterization and in vitro cytocompatibility analysis,” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, pp. 0–0, 2017, Accessed: 00, 2020. [Online]. Available: