The first enzymatic resolution of quaternary alpha-acetoxy alpha-substituted cyclic ketones

Date

2006-04-03

Author

Tanyeli, Cihangir
Akhmedov, Idris M.
İYİGÜN, Cigdem

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The enantioselective resolution of quaternary alpha-acetoxy alpha-substituted indanone and 1-tetralone derivatives was performed with commercially available enzyme CRL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantoselectivities were tested, and the optimal enzymatic resolution condition was found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ees (varied between 81% and 85%).

Subject Keywords

Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/47627

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2006.04.012

Collections

Department of Chemistry, Article

Citation Formats

C. Tanyeli, I. M. Akhmedov, and C. İYİGÜN, “The first enzymatic resolution of quaternary alpha-acetoxy alpha-substituted cyclic ketones,” TETRAHEDRON-ASYMMETRY, vol. 17, no. 7, pp. 1125–1128, 2006, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47627.