The first enzymatic resolution of quaternary alpha '-acetoxy alpha,beta-unsaturated cyclohexenones and cyclopentenones

Date

2005-12-12

Author

Tanyeli, Cihangir
Ozdemirhan, FD
Iyigun, CEM

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The enantio selective resolution of various quaternary alpha'-acetoxy alpha,beta-unsaturated cyclohexenones and cyclopentenones was performed with the commercially available enzyme CCL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantioselectivities were tested and the best enzymatic resolution conditions were found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ee varying between 36% and 99%.

Subject Keywords

Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/44843

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2005.11.016

Collections

Department of Chemistry, Article

Citation Formats

C. Tanyeli, F. Ozdemirhan, and C. Iyigun, “The first enzymatic resolution of quaternary alpha ’-acetoxy alpha,beta-unsaturated cyclohexenones and cyclopentenones,” TETRAHEDRON-ASYMMETRY, vol. 16, no. 24, pp. 4050–4055, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/44843.