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The first enzymatic resolution of quaternary alpha '-acetoxy alpha,beta-unsaturated cyclohexenones and cyclopentenones

2005-12-12
Tanyeli, Cihangir
Ozdemirhan, FD
Iyigun, CEM
The enantio selective resolution of various quaternary alpha'-acetoxy alpha,beta-unsaturated cyclohexenones and cyclopentenones was performed with the commercially available enzyme CCL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantioselectivities were tested and the best enzymatic resolution conditions were found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ee varying between 36% and 99%.