Kinetics of amino acid production by over-producer mutant microorganisms

Özilgen, Mustafa
Experimental data were modeled based on the literature for the production of nine different amino acids by ten different mutant over-producer microorganisms. Mathematical modeling helped to better understand common aspects of these fermentations, which were not stressed previously by plotting the data only. A Luedeking-Piret type of a model was found to be valid for representing all the amino acid production data. This result indicated the similarity among the amino acid production patterns of all the mutant microorganisms concerned. The results also indicated that amino acid production by the mutant microorganisms was mostly non-growth associated, and that the substrate was allocated by all the microorganisms, mainly for biomass and amino acid production. The amino acid production pattern of the microorganisms did not change when the microorganisms reached the stationary phase, but the depletion of the substrate stopped production immediately.
Enzyme and Microbial Technology


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Citation Formats
M. Özilgen, “Kinetics of amino acid production by over-producer mutant microorganisms,” Enzyme and Microbial Technology, pp. 110–114, 1988, Accessed: 00, 2020. [Online]. Available: