Conversion of homochiral amines, beta-amino alcohols and alpha-amino acids to their chiral 2-substituted pyrrole derivatives

Date

2001-01-01

Author

Demir, Ayhan Sıtkı
Akhmedov, IM
Sesenoglu, O
Alpturk, O
Apaydin, S
Gercek, Z
Ibrahimzade, N

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The conversion of the amino group of chiral amines, amino alcohols, amino acids and their esters into chiral 2-substituted pyrrole derivatives with various halogeno enones is described. The conversion works in good yield and without racemization. The synthesis of 2-phenylpyrrole derivatives was possible with amino alcohols but not with amino acids or their esters

URI

https://hdl.handle.net/11511/52147

Journal

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

DOI

https://doi.org/10.1039/b008317h

Collections

Department of Chemistry, Article

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Synthesis of n-(2-propylphenyl) substituted chiral amino alcohols and their usage in enantioselective diethylzinc addition reactions Günler, Zeynep İnci; Tanyeli, Cihangir; Department of Chemistry (2011) IChiral 1,2-amino alcohols were synthesized via newly developed “intramolecular unsaturation transfer” using cyclohexanone, propargyl bromide, and various chiral amino alcohols as starting components. These amino alcohols can be potential chiral ligands for many asymmetric transformation reactions. Therefore, their effectiveness as chiral ligands in diethylzinc addition to benzaldehyde and N-diphenylphosphinoyl imines were tested. Various parameters including temperature, solvent, ligand amount etc. were sc...

Citation Formats

A. S. Demir et al., “Conversion of homochiral amines, beta-amino alcohols and alpha-amino acids to their chiral 2-substituted pyrrole derivatives,” JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, pp. 1162–1167, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52147.