Synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives from 2-(2-bromoallyl)-1,3-dicarbonyl compounds

Date

2002-12-02

Author

Demir, Ayhan Sıtkı
Akhmedov, IM
Sesenoglu, O

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2-(2-Bromoallyl)-1,3-dicarbonyl compounds are converted into beta-enamino, beta-hydrazino esters and ketones, followed by base-promoted cyclization, leading to the formation of the corresponding 1,2,3,5-tetrasubstituted pyrroles. 1,2,4- and 1,2,3,4-Substituted pyrroles are also isolated as minor products. Starting from the 2-(2-bromoallyl)-cyclohexane-1,3-dione the corresponding tetrahydro indolone is prepared in good yield.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/51515

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/s0040-4020(02)01298-x

Collections

Department of Chemistry, Article

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Citation Formats

A. S. Demir, I. Akhmedov, and O. Sesenoglu, “Synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives from 2-(2-bromoallyl)-1,3-dicarbonyl compounds,” TETRAHEDRON, pp. 9793–9799, 2002, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51515.