Selective synthesis of N-substituted pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives via alkyne cyclization

2014-12-03
Cetinkaya, Yasin
Balcı, Metin
A novel and efficient synthesis of N-substituted pyrrolo-pyrazinone derivatives has been developed. A trichloroacetyl group connected to the pyrrole ring was converted into the desired carboxamide derivatives. Promoted by NaH, the pyrrole carboxamide derivatives underwent a tandem reaction with propargyl bromide to afford pyrrolo-pyrazinones with high efficiency under very mild conditions. The mechanism for the formation of the products is discussed and supported by DFT calculations. (C) 2014 Elsevier Ltd. All rights reserved
TETRAHEDRON LETTERS

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Citation Formats
Y. Cetinkaya and M. Balcı, “Selective synthesis of N-substituted pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives via alkyne cyclization,” TETRAHEDRON LETTERS, pp. 6698–6702, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52338.