Disruption of hom gene of Streptomyces clavuligerus and its effects on cephamycin C yields

Caydasi, A. Koca
Yilmaz, E. Ince
Özcengiz, Gülay


Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism
Liu, Xiling; Han, Dingding; Somel, Mehmet; Jiang, Xi; Hui, Haiyang; Guijarro, Patricia; Zhang, Ning; Mitchell, Amanda; Halene, Tobias; Ely, John J.; Sherwood, Chet C.; Hof, Patrick R.; Qiu, Zilong; Paeaebo, Svante; Akbarian, Schahram; Khaitovich, Philipp (2016-09-01)
Cognitive defects in autism spectrum disorder (ASD) include socialization and communication: key behavioral capacities that separate humans from other species. Here, we analyze gene expression in the prefrontal cortex of 63 autism patients and control individuals, as well as 62 chimpanzees and macaques, from natal to adult age. We show that among all aberrant expression changes seen in ASD brains, a single aberrant expression pattern overrepresented in genes involved synaptic-related pathways is enriched in...
Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatin-metformin combination treatment
Durukan, O.; Akkulak, M.; Evin, E.; ARSLAN, SEHER; Adalı, Orhan (2018-07-01)
Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatinmetformin combination treatment
Durukan, Özlem; Akkulak, Merve; Evin, Emre; Arslan, Şevki; Adalı, Orhan (null; 2018-07-01)
Metformin is an antidiabetic drug with anticancer properties. Cisplatin is known as one of the most potent chemotherapeutics for treatment of various types of cancer. In order to overcome cisplatin resistance and toxicity, the drug can be combined with other drugs that sensitize tumour cells to cisplatin. The ability of metformin to potentiate cisplatin-mediated killing of cancer cells in vitro, makes it a plausible candidate for combination with cisplatin- based therapy. The aim of this study is to examine...
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
Baran, Yusuf; Salas, Arelis; Senkal, Can E.; Gündüz, Ufuk; Bielawski, Jacek; Obeid, Lina M.; Ogretmen, Besim (2007-04-13)
In this study, mechanisms of resistance to imatinib-induced apoptosis in human K562 cells were examined. Continuous exposure to stepwise increasing concentrations of imatinib resulted in the selection of K562/IMA-0.2 and -1 cells, which expressed similar to 2.3- and 19-fold resistance, respectively. Measurement of endogenous ceramides by high performance liquid chromatography/mass spectroscopy showed that treatment with imatinib increased the generation of ceramide, mainly C-18-ceramide, which is generated ...
ALTAY, AHMET; İrtem Kartal, Deniz; Sagdicoglu-Celep, Gulcin; Güray, Nülüfer Tülün; Bozoglu, Faruk (2018-01-01)
Propolis, which is a complex resinous material has diverse pharmacological and biological properties. Phase I and II enzymes are responsible for detoxication and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in metabolic activation of xenobiotics. This study was designed to investigate the in vitro modulatory effects of Anatolian propolis and its phenolic contents; caffeic acid, quercetin and p-coumaric acid on t...
Citation Formats
A. K. Caydasi, E. I. Yilmaz, and G. Özcengiz, “Disruption of hom gene of Streptomyces clavuligerus and its effects on cephamycin C yields,” 2006, vol. 273, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52977.