Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatin-metformin combination treatment

Durukan, O.
Akkulak, M.
Evin, E.
Adalı, Orhan


Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatinmetformin combination treatment
Durukan, Özlem; Akkulak, Merve; Evin, Emre; Arslan, Şevki; Adalı, Orhan (null; 2018-07-01)
Metformin is an antidiabetic drug with anticancer properties. Cisplatin is known as one of the most potent chemotherapeutics for treatment of various types of cancer. In order to overcome cisplatin resistance and toxicity, the drug can be combined with other drugs that sensitize tumour cells to cisplatin. The ability of metformin to potentiate cisplatin-mediated killing of cancer cells in vitro, makes it a plausible candidate for combination with cisplatin- based therapy. The aim of this study is to examine...
Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells
ALTAY, AHMET; İrtem Kartal, Deniz; SADİ, GÖKHAN; Güray, Nülüfer Tülün; YAPRAK, AHMET EMRE (2017-01-01)
Phase I-II detoxification and antioxidant enzymes are responsible for the detoxification and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in the metabolic activation of xenobiotics. The herb Salicornia freitagii (SF) (Amaranthaceae) is known for its anticancer, antioxidant, antidiabetic and antiinflammatory activities. In this study, we determined the bioactive phenolics in the SF methanol extract and investigat...
Modulation of protein and mRNA expressions of rat liver vitamin D3 metabolizing CYP27B1 by o-coumaric acid
Adalı, Orhan; Karakurt, S.; ŞEN, ALAATTİN (2013-07-01)
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
Baran, Yusuf; Salas, Arelis; Senkal, Can E.; Gündüz, Ufuk; Bielawski, Jacek; Obeid, Lina M.; Ogretmen, Besim (2007-04-13)
In this study, mechanisms of resistance to imatinib-induced apoptosis in human K562 cells were examined. Continuous exposure to stepwise increasing concentrations of imatinib resulted in the selection of K562/IMA-0.2 and -1 cells, which expressed similar to 2.3- and 19-fold resistance, respectively. Measurement of endogenous ceramides by high performance liquid chromatography/mass spectroscopy showed that treatment with imatinib increased the generation of ceramide, mainly C-18-ceramide, which is generated ...
Alterations in zinc status and tissue structures of heparin-induced osteoporotic rabbits
Turan, B; Zaloglu, N; Saran, Y; Konukseven, E; Koc, E (Dustri-Verlgag Dr. Karl Feistle, 2004-01-01)
Heparin can cause some complications in tissues when it is used for long-term therapy. Besides its beneficial effects, it may have some side effects. In this study, we investigated the possible hematological and histopathological changes in rabbit tissues under long-term (1 month) and overdoses (1,000 and 2,000 IU/kg/day) heparin applications. Group 1 was injected with serum physiologic and kept as control while Groups 2 and 3 were injected with heparin as dosages of 1,000 IU/kg/day and 2,000 IU/kg/ day, re...
Citation Formats
O. Durukan, M. Akkulak, E. Evin, S. ARSLAN, and O. Adalı, “Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatin-metformin combination treatment,” FEBS OPEN BIO, pp. 352–352, 2018, Accessed: 00, 2020. [Online]. Available: