Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatin-metformin combination treatment

Date

2018-07-01

Author

Durukan, O.
Akkulak, M.
Evin, E.
ARSLAN, SEHER
Adalı, Orhan

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https://hdl.handle.net/11511/53553

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FEBS OPEN BIO

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Department of Biology, Article

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Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatinmetformin combination treatment Durukan, Özlem; Akkulak, Merve; Evin, Emre; Arslan, Şevki; Adalı, Orhan (null; 2018-07-01) Metformin is an antidiabetic drug with anticancer properties. Cisplatin is known as one of the most potent chemotherapeutics for treatment of various types of cancer. In order to overcome cisplatin resistance and toxicity, the drug can be combined with other drugs that sensitize tumour cells to cisplatin. The ability of metformin to potentiate cisplatin-mediated killing of cancer cells in vitro, makes it a plausible candidate for combination with cisplatin- based therapy. The aim of this study is to examine...
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Citation Formats

O. Durukan, M. Akkulak, E. Evin, S. ARSLAN, and O. Adalı, “Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatin-metformin combination treatment,” FEBS OPEN BIO, pp. 352–352, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/53553.