Synthesis of pyridines via electrophilic cyclization of N-propargylic beta-enaminones

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2012-03-25

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Zora, Metin

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https://hdl.handle.net/11511/55314

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Synthesis of Pyrazoles via Cul-Mediated Electrophilic Cyclizations of alpha,beta-Alkynic Hydrazones Zora, Metin (2011-11-18) Synthesis of pyrazoles via electrophilic cyclization of alpha,beta-alkynic hydrazones by copper(I) iodide is described. When treated with copper(I) iodide in the presence of triethylamine in refluxing acetonitrile, alpha,beta-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electrophilic cyclization to afford pyrazole derivatives in good to excellent yields. The reaction appears to be general for a variety of alpha,beta-alkynic hydrazones and tolerates the pr...
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Synthesis of thienopyridinones via hydrazide-alkyne cyclization Cokol, Nalan Korkmaz; Erden, Kübra; Gunay, Furkan Melih; Dengiz, Çağatay; Balci, Metin (Elsevier BV, 2020-05-08) A novel and efficient method for the synthesis of thieno[3,2-c]pyridinones have been developed. The synthetic strategy relies on the synthesis of halothiophene esters utilized as substrates for subsequent Sonogashira cross-coupling reactions. Hydrazinolysis of corresponding esters and following hydrazidealkyne ring closure transformations resulted in target thienopyridinones in good yields. It is also shown that pure hydrazine monohydrate is required to facilitate the hydrazide formations.

Citation Formats

M. Zora, “Synthesis of pyridines via electrophilic cyclization of N-propargylic beta-enaminones,” 2012, vol. 243, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55314.