Synthesis of beta-chloro-alpha-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates

Date

2018-12-02

Author

Polat-Cakir, Sidika
BEKSULTANOVA, Nurzhan
Doğan, Özdemir

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A series of unactivated racemic and chiral aziridine-2-phosphonates were synthesized by modified Gabriel-Cromwell reaction. Ring opening reaction of the synthesized phosphonates by gaseous HCl provided access to a wide range of biologically interesting novel beta-chloro-alpha-aminophosphonates. All reactions toward each of the above-mentioned products can be conducted regioselectively in high yields.

Subject Keywords

Inorganic Chemistry, Organic Chemistry, Biochemistry

URI

https://hdl.handle.net/11511/46586

Journal

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

DOI

https://doi.org/10.1080/10426507.2018.1513521

Collections

Department of Chemistry, Article

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Citation Formats

S. Polat-Cakir, N. BEKSULTANOVA, and Ö. Doğan, “Synthesis of beta-chloro-alpha-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates,” PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, pp. 858–864, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/46586.