Synthesis of beta-chloro-alpha-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates

Polat-Cakir, Sidika
Doğan, Özdemir
A series of unactivated racemic and chiral aziridine-2-phosphonates were synthesized by modified Gabriel-Cromwell reaction. Ring opening reaction of the synthesized phosphonates by gaseous HCl provided access to a wide range of biologically interesting novel beta-chloro-alpha-aminophosphonates. All reactions toward each of the above-mentioned products can be conducted regioselectively in high yields.


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Citation Formats
S. Polat-Cakir, N. BEKSULTANOVA, and Ö. Doğan, “Synthesis of beta-chloro-alpha-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates,” PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, pp. 858–864, 2018, Accessed: 00, 2020. [Online]. Available: