A novel lanthanide complex with remarkable phosphodiester transesterification activity and DNA-conjugatable functionality

Baykal, U
Akkaya, Mahinur
Akkaya, EU
Encapsulated lanthanide complexes like the TCMC complexes are highly stable under physiological conditions. With the ultimate goal being an in vivo application of these complexes as a sequence-selective RNA/DNA cleaving agent (artificial RNAse/DNAse), kinetic stability of the complex would be a distinct advantage. We have synthesized a novel lanthanide complex with such stability and which displays high transesterification activity. The most important attribute of this compound is the nitrophenyl group which would allow further derivatization and conjugation to a DNA oligomer, thus creating a potential for the sequence selective hydrolysis of its target.


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Various lanthanide complexes have been shown to promote phosphodiester hydrolysis. Distribution of the available coordination sites of the lanthanides between the ligand and the labile water molecules has proved to be critical in determining the activity and stability of the complex in water at neutral pH. Since the final goal is to conjugate such hydrolytically active molecules to DNA oligomers, the design must include a functionality that can be made reactive in standard conjugation protocols. To that end...
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Citation Formats
U. Baykal, M. Akkaya, and E. Akkaya, “A novel lanthanide complex with remarkable phosphodiester transesterification activity and DNA-conjugatable functionality,” JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, pp. 311–315, 1999, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56598.