Synthesis of new 4-aza-indoles via acyl azides

Date

2015-01-14

Author

Dogan, Sengul Dilem
DEMİRPOLAT, Eren
Aycan, Mukerrem Betul Yerer
Balcı, Metin

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We hereby report the preparation of new azaindole derivatives starting from 2-(2-ethoxy-2-oxoethyl) nicotinic acid. Conversion of a half ester into acyl azide followed by Curtius rearrangement gave the corresponding isocyanate. Trapping of the isocyanate with different nucleophiles produced urea and urethane derivatives. Intramolecular cyclization reactions gave the target compounds.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/57522

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2014.11.057

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

S. D. Dogan, E. DEMİRPOLAT, M. B. Y. Aycan, and M. Balcı, “Synthesis of new 4-aza-indoles via acyl azides,” TETRAHEDRON, pp. 252–258, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57522.