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Synthesis of new 4-aza-indoles via acyl azides

Dogan, Sengul Dilem
Aycan, Mukerrem Betul Yerer
Balcı, Metin
We hereby report the preparation of new azaindole derivatives starting from 2-(2-ethoxy-2-oxoethyl) nicotinic acid. Conversion of a half ester into acyl azide followed by Curtius rearrangement gave the corresponding isocyanate. Trapping of the isocyanate with different nucleophiles produced urea and urethane derivatives. Intramolecular cyclization reactions gave the target compounds.