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Catalytic Intermolecular Aldehyde-Ketone Coupling via Acyl Phosphonates

2009-03-06
Demir, Ayhan Gürbüz
Esiringue, Iker
Gollu, Mehmet
Reis, Oemer
The first catalytic intermolecular aldehyde-ketone coupling via acyl phosphonate is reported. Acyl phosphonates are potent acyl anion precursors, which generate acyl anion equivalents under the influence of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with activated ketones to form acyloin type coupling in 41-95% yields.