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Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy
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Date
2009-01-14
Author
Ozlem, Suriye
AKKAYA, Engin Umut
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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A simple derivative of a welt-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ion concentration and acidity. Singlet oxygen generation rate is maximal when sodium ions and an organic acid were added. The operation of this molecular automaton follows AND logic, which introduces an additional layer of selectivity in the photodynamic action of the reagent. It should also be noted that in this system sensing, computing and actuating functions are realized within a single molecule.
Subject Keywords
Distyryl-boradiazaindacenes
,
Gate
,
Half-subtractor
,
Bodipy dyes
,
Elements
,
Efficient
,
Chemistry
URI
https://hdl.handle.net/11511/65841
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
DOI
https://doi.org/10.1021/ja808389t
Collections
Department of Chemistry, Article