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Performance of Antenatal Diagnostic Criteria of Twin-Anemia-Polycythemia Sequence
Date
2020-09-01
Author
Liu, Becky
Kalafat, Erkan
Bhide, Amar
Thilaganathan, Basky
Khalil, Asma
Metadata
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This study aims to elicit the validation performance of different diagnostic criteria and to evaluate the disease course and perinatal outcomes of pregnancies complicated by twin anemia polycythemia sequence (TAPS). Monochorionic diamniotic (MCDA) twin pregnancies who received serial middle cerebral artery (MCA) peak systolic velocity (PSV) measurements without non-TAPS-related demise or major anomalies were included. Course of disease, antenatal intervention, additional ultrasound features, and perinatal outcomes were compared between each criteria and onset. Forty-nine cases of TAPS and 203 non-TAPS controls were identified. The incidence of TAPS was 19.2%, 15.7%, 7.8%, and 6.3% for Delta PSV MoM > 0.373, Delta PSV MoM > 0.5, traditional, and Delphi consensus criteria, respectively (p 0.373 (87.0 vs. 59.0%,p= 0.037). TAPS had a significantly higher birth weight discordance than uncomplicated MCDA twins (25.3 vs. 7.3%,p 0.373 criteria identified milder cases, without a significant impact on neonatal outcomes.
Subject Keywords
Twin anemia polycythemia sequence
,
Diagnostic criteria
,
Perinatal outcomes
,
Disease progression
,
Antenatal intervention
URI
https://hdl.handle.net/11511/67920
Journal
JOURNAL OF CLINICAL MEDICINE
DOI
https://doi.org/10.3390/jcm9092754
Collections
Department of Statistics, Article
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B. Liu, E. Kalafat, A. Bhide, B. Thilaganathan, and A. Khalil, “Performance of Antenatal Diagnostic Criteria of Twin-Anemia-Polycythemia Sequence,”
JOURNAL OF CLINICAL MEDICINE
, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67920.