Performance of Antenatal Diagnostic Criteria of Twin-Anemia-Polycythemia Sequence

Liu, Becky
Kalafat, Erkan
Bhide, Amar
Thilaganathan, Basky
Khalil, Asma
This study aims to elicit the validation performance of different diagnostic criteria and to evaluate the disease course and perinatal outcomes of pregnancies complicated by twin anemia polycythemia sequence (TAPS). Monochorionic diamniotic (MCDA) twin pregnancies who received serial middle cerebral artery (MCA) peak systolic velocity (PSV) measurements without non-TAPS-related demise or major anomalies were included. Course of disease, antenatal intervention, additional ultrasound features, and perinatal outcomes were compared between each criteria and onset. Forty-nine cases of TAPS and 203 non-TAPS controls were identified. The incidence of TAPS was 19.2%, 15.7%, 7.8%, and 6.3% for Delta PSV MoM > 0.373, Delta PSV MoM > 0.5, traditional, and Delphi consensus criteria, respectively (p 0.373 (87.0 vs. 59.0%,p= 0.037). TAPS had a significantly higher birth weight discordance than uncomplicated MCDA twins (25.3 vs. 7.3%,p 0.373 criteria identified milder cases, without a significant impact on neonatal outcomes.

Citation Formats
B. Liu, E. Kalafat, A. Bhide, B. Thilaganathan, and A. Khalil, “Performance of Antenatal Diagnostic Criteria of Twin-Anemia-Polycythemia Sequence,” JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 9, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: