Performance of Antenatal Diagnostic Criteria of Twin-Anemia-Polycythemia Sequence

Date

2020-09-01

Author

Liu, Becky
Kalafat, Erkan
Bhide, Amar
Thilaganathan, Basky
Khalil, Asma

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This study aims to elicit the validation performance of different diagnostic criteria and to evaluate the disease course and perinatal outcomes of pregnancies complicated by twin anemia polycythemia sequence (TAPS). Monochorionic diamniotic (MCDA) twin pregnancies who received serial middle cerebral artery (MCA) peak systolic velocity (PSV) measurements without non-TAPS-related demise or major anomalies were included. Course of disease, antenatal intervention, additional ultrasound features, and perinatal outcomes were compared between each criteria and onset. Forty-nine cases of TAPS and 203 non-TAPS controls were identified. The incidence of TAPS was 19.2%, 15.7%, 7.8%, and 6.3% for Delta PSV MoM > 0.373, Delta PSV MoM > 0.5, traditional, and Delphi consensus criteria, respectively (p 0.373 (87.0 vs. 59.0%,p= 0.037). TAPS had a significantly higher birth weight discordance than uncomplicated MCDA twins (25.3 vs. 7.3%,p 0.373 criteria identified milder cases, without a significant impact on neonatal outcomes.

Subject Keywords

Twin anemia polycythemia sequence, Diagnostic criteria, Perinatal outcomes, Disease progression, Antenatal intervention

URI

https://hdl.handle.net/11511/67920

Journal

JOURNAL OF CLINICAL MEDICINE

DOI

https://doi.org/10.3390/jcm9092754

Collections

Department of Statistics, Article

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Citation Formats

B. Liu, E. Kalafat, A. Bhide, B. Thilaganathan, and A. Khalil, “Performance of Antenatal Diagnostic Criteria of Twin-Anemia-Polycythemia Sequence,” JOURNAL OF CLINICAL MEDICINE, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67920.