PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)

Seza, Esin Gülce
Güderer, İsmail
Ermis, Çagdas
Banerjee, Sreeparna
© 2019 Atlas of Genetics and Cytogenetics in Oncology and Haematology.Protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), also known as AMPK α1, is an energy sensor that plays a key role in the regulation of cellular energy metabolism. AMPK α1 is the catalytic subunit of the heterotrimeric AMPK protein with a length of 548 amino acids. A key switch to activate this protein is an alteration in the AMP/ATP ratio. The protein is dysregulated in several human diseases including diabetes and metabolic syndrome, cardiovascular diseases, neurodegenerative diseases and many cancer types (Steinberg and Kemp, 2009). Two isoforms of AMPK exist including AMPK α1 and AMPK α2; however, discrimination between these isoforms for their involvement in certain diseases is currently not possible.
Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Kiriş, Erkan; Yanpallewar, S; Dorsey, SG; Becker, J; Bavari, S; Palko, ME; Coppola, V; Tessarollo, L (2014-03-12)
TrkA is a tyrosine kinase receptor required for development and survival of the peripheral nervous system. In the adult, TrkA and its ligand NGF are peripheral pain mediators, particularly in inflammatory pain states. However, how TrkA regulates the function of nociceptive neurons and whether its activity levels may lead to sensory abnormalities is still unclear. Here we report the characterization of a 3 aa (KFG) domain that negatively regulates TrkA level and function in response to NGF. Deletion of this ...
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The MAPK (mitogen-activated protein kinase) or its synonymous ERK (extracellular signal regulated kinase) pathway whose components are Ras, Raf, and MEK proteins with many biochemical links, is one of the major signalling systems involved in cellular growth control of eukaryotes including cell proliferation, transformation, differentiation, and apoptosis. In this study we describe the MAPK/ERK pathway via (quasi) biochemical reactions and then implement the pathway by a stochastic Markov process. A novelty ...
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Güldüren, Zerrin; Kence, Meral; Department of Biology (2008)
Phosphoglucomutase (PGM) is one of the central enzymes in energy metabolism at a branch point at the head of the metabolic pathway leading into glycogen metabolism, pentose shunt and the main glycolytic cycle, catalyzing the reversible interconversion of glucose-1-phosphate to glucose-6-phosphate. Whole year, month to month analysis of pattern of allozyme variation at Pgm and Hk loci in Apis mellifera L. from three provinces; Kırklareli, Artvin, and Hatay revealed that there is significant seasonal variatio...
Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery
Lester, Henry A.; Xiao, Cheng; Srinivasan, Rahul; Son, Çağdaş Devrim; Miwa, Julie; Pantoja, Rigo; Banghart, Matthew R.; Dougherty, Dennis A.; Goate, Alison M.; Wang, Jen C. (2009-03-01)
The acronym SePhaChARNS, for "selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry," is introduced. We hypothesize that SePhaChARNS underlies classical observations that chronic exposure to nicotine causes "upregulation" of nicotinic receptors (nAChRs). If the hypothesis is proven, (1) SePhaChARNS is the molecular mechanism of the first step in neuroadaptation to chronic nicotine; and (2) nicotine addiction is partially a disease of excessive chaperoning. The chaperone is...
Citation Formats
E. G. Seza, İ. Güderer, Ç. Ermis, and S. Banerjee, “PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1),” Atlas of Genetics and Cytogenetics in Oncology and Haematology, pp. 105–111, 2019, Accessed: 00, 2020. [Online]. Available: