Dielectrophoretic detection of multidrug resistance in cancer

Date

2015-06-12

Author

Demircan Yalçın, Yağmur
Özgür, Ebru
Gündüz, Ufuk
Külah, Haluk

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https://hdl.handle.net/11511/79698

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Dielectrophoretic detection of imatinib resistance in K562 Cells Using A lab-on-a-chip system Demircan Yalçın, Yağmur; Toral, Taylan Berkın; Sukaş, Serkan; Yıldırım, Ender; Zorlu, Özge; Gündüz, Ufuk; Külah, Haluk (Chemical and Biological Microsystems Society (CBMS); 2019-10-27) This study presents label-free detection of imatinib resistance in K562 cells via integrated dielectrophoretic detection and impedimetric counting on a lab-on-a-chip system. Two impedimetric counting units were placed upstream and downstream of dielectrophoretic detection unit to obtain differential cell count and consequently the trapping ratio. The trapping ratio up to 57% was achieved for imatinib resistant (~60-fold) K562 cells, while it was minimized to 20% for wild type K562 cells
Dielectrophoretic Spectra of Polymorphonuclear White Blood Cells Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Özkayar, Gürhan; Özgür, Ebru; Külah, Haluk (null; 2016-10-07)
Dielectrophoretic Separation of K562 Human Leukemia Cells From Leukocytes by Isolated 3D Electrodes Bahrieh, Garsha; Özgür, Ebru; Külah, Haluk (null; 2014-09-03) This paper presents the design, simulation, and fabrication of a MEMS based dielectrophoresis (DEP) platform for the separation and detection of the human leukemic cancer cells (K562) and its multidrug resistant (MDR) counterpart (K56/IMA-0.2 µM) from the human leukocyte mixture. The pro-posed DEP device, benefits from the 3D isolated electrodes inside a microfluidic channel. 3D elec-trodes (extruded 30 µm in z-direction) were isolated from the medium with thin parylene coating (~ 0.3 µm). In addition, the ...
Dielectrophoretic Spectra of CD133+/EpCAM+ HUH7 Cancer Stem Cells and HUH7 Cancer Cells Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Özkayar, Gürhan; Kahraman, Deniz Cansen; Atalay, Rengül; Özgür, Ebru; Külah, Haluk (2016-07-15)
Dielectrophoresis in microfluidics technology ÇETİN, BARBAROS; Li, Dongqing (2011-09-01) Dielectrophoresis (DEP) is the movement of a particle in a non-uniform electric field due to the interaction of the particle's dipole and spatial gradient of the electric field. DEP is a subtle solution to manipulate particles and cells at microscale due to its favorable scaling for the reduced size of the system. DEP has been utilized for many applications in microfluidic systems. In this review, a detailed analysis of the modeling of DEP-based manipulation of the particles is provided, and the recent appl...

Citation Formats

Y. Demircan Yalçın, E. Özgür, U. Gündüz, and H. Külah, “Dielectrophoretic detection of multidrug resistance in cancer,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/79698.