Dielectrophoretic detection of imatinib resistance in K562 Cells Using A lab-on-a-chip system

Date

2019-10-27

Author

Demircan Yalçın, Yağmur
Toral, Taylan Berkın
Sukaş, Serkan
Yıldırım, Ender
Zorlu, Özge
Gündüz, Ufuk
Külah, Haluk

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This study presents label-free detection of imatinib resistance in K562 cells via integrated dielectrophoretic detection and impedimetric counting on a lab-on-a-chip system. Two impedimetric counting units were placed upstream and downstream of dielectrophoretic detection unit to obtain differential cell count and consequently the trapping ratio. The trapping ratio up to 57% was achieved for imatinib resistant (~60-fold) K562 cells, while it was minimized to 20% for wild type K562 cells

Subject Keywords

Dielectrophoresis, Imatinib resistance, Impedimetric counting, Lab-on-a-chip, Label-free detection

URI

https://hdl.handle.net/11511/87148

Conference Name

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, 27 October 2019 through 31 October 2019

Collections

Department of Mechanical Engineering, Conference / Seminar

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Citation Formats

Y. Demircan Yalçın et al., “Dielectrophoretic detection of imatinib resistance in K562 Cells Using A lab-on-a-chip system,” Basel; Switzerland, 2019, p. 1358, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/87148.