Notable Decrease in Transcriptome Conservation During Mammalian Brain Aging

Turan, Zeliha Gözde
Somel, Mehmet


Notable decrease in transcriptome conservation during mammalian aging
Turan, Zeliha Gözde; Somel, Mehmet; Department of Biology (2016)
Aging is a complex process that causes decline in organisms’ reproductive capacity and chance of survival. Even though aging tends to reduce fitness, it is not eliminated by natural selection and is observed in many multicellular species, and this leads to an evolutionary paradox. The mutation accumulation theory states that due to the declining force of natural selection with age, old-age-expressed deleterious mutations will not be effectively eliminated, and can contribute to the aging phenotype. A limite...
Remarkable cooperative action of two zinc centers in the hydrolysis of plasmid DNA
Aka, FN; Akkaya, Mahinur; Akkaya, EU (Elsevier BV, 2001-01-08)
A novel binuclear zinc complex has been synthesized. The complex is highly efficient in the hydrolysis of plasmid DNA at pH 7.5. Furthermore, a comparison to a mononuclear complex reveals a high level of cooperativity between the two metal ion centers.
Differential expression of archaeal Hsp60 and CDC48 homologue VAT genes in heat shock
Kocabıyık, Semra; Demirok, B. (2007-07-01)
Targeted disruption of homoserine dehydrogenase gene in Streptomyces clavuligerus and its effects on cephamycin C production
Çaydaşı (Koca), Ayşe; Özcengiz, Gülay; Department of Biology (2006)
The members of the genus Streptomyces are well-known for their capacity to synthesize a vast repertoire of secondary metabolites, including many useful antibiotics and proteins. Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics such as cephamycin C and the potent β-lactamase inhibitor clavulanic acid. The aspartate pathway of S. clavuligerus is an important primary metabolic pathway providing substrates for β-lactam synthesis. This pathway uses L-aspartic acid as the ...
Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease
Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2013-03-01)
Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).
Citation Formats
Z. G. Turan and M. Somel, “Notable Decrease in Transcriptome Conservation During Mammalian Brain Aging,” 2015, Accessed: 00, 2021. [Online]. Available: