Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease

Hirschmann, J.
Özkurt, Tolga Esat
Butz, M.
Homburger, M.
Elben, S.
Hartmann, C. J.
Vesper, J.
Wojtecki, L.
Schnitzler, A.
Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).


A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease
Hirschmann, Jan; Hartmann, Christian J.; Butz, Markus; Hoogenboom, Nienke; Özkurt, Tolga Esat; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2013-12-01)
Electrophysiological studies suggest that rest tremor in Parkinson's disease is associated with an alteration of oscillatory activity. Although it is well known that tremor depends on cortico-muscular coupling, it is unclear whether synchronization within and between brain areas is specifically related to the presence and severity of tremor. To tackle this longstanding issue, we took advantage of naturally occurring spontaneous tremor fluctuations and investigated cerebral synchronization in the presence an...
Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease
Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2011-04-01)
Neuronal oscillations are assumed to play a pivotal role in the pathophysiology of Parkinson's disease (PD). Neurons in the subthalamic nucleus (STN) generate oscillations which are coupled to rhythmic population activity both in other basal ganglia nuclei and cortical areas.
High frequency oscillations in the subthalamic nucleus: A neurophysiological marker of the motor state in Parkinson's disease
Özkurt, Tolga Esat; Butz, Markus; Homburger, Melanie; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2011-06-01)
Increasing evidence suggests that abnormal oscillatory activity in basal ganglia and cortex plays a pivotal role in the pathophysiology of Parkinson's disease. Recordings of local field potentials from subthalamic nucleus of patients undergoing deep brain stimulation have focused on oscillations occurring at frequencies below 100 Hz in the alpha, beta and gamma range and suggested that, in particular, an increase of beta band oscillations underlies slowing of movement in Parkinson's disease. Recent findings...
Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations
Hirschmann, Jan; Butz, Markus; Hartmann, Christian J.; Hoogenboom, Nienke; Özkurt, Tolga Esat; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2016-10-01)
BackgroundHigh frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement.
Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington's disease
Paraskevopoulou, Foteini; Parvizi, Poorya; Senger, Gokce; Tunçbağ, Nurcan; Rosenmund, Christian; Yildirim, Ferah (2021-05-11)
Transcriptional dysregulation in Huntington's disease (HD) causes functional deficits in striatal neurons. Here, we performed Patchsequencing (Patch-seq) in an in vitro HD model to investigate the effects of mutant Huntingtin (Htt) on synaptic transmission and gene transcription in single striatal neurons. We found that expression of mutant Htt decreased the synaptic output of striatal neurons in a cell autonomous fashion and identified a number of genes whose dysregulation was correlated with physiological...
Citation Formats
J. Hirschmann et al., “Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson’s disease,” NEUROIMAGE, pp. 203–213, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31584.