Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease

Date

2013-03-01

Author

Hirschmann, J.
Özkurt, Tolga Esat
Butz, M.
Homburger, M.
Elben, S.
Hartmann, C. J.
Vesper, J.
Wojtecki, L.
Schnitzler, A.

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Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).

Subject Keywords

Parkinson's disease, Oscillations, MEG, Coherence, STN, Deep brain stimulation

URI

https://hdl.handle.net/11511/31584

Journal

NEUROIMAGE

DOI

https://doi.org/10.1016/j.neuroimage.2012.11.036

Collections

Graduate School of Informatics, Article

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Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2011-04-01) Neuronal oscillations are assumed to play a pivotal role in the pathophysiology of Parkinson's disease (PD). Neurons in the subthalamic nucleus (STN) generate oscillations which are coupled to rhythmic population activity both in other basal ganglia nuclei and cortical areas.
High frequency oscillations in the subthalamic nucleus: A neurophysiological marker of the motor state in Parkinson's disease Özkurt, Tolga Esat; Butz, Markus; Homburger, Melanie; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2011-06-01) Increasing evidence suggests that abnormal oscillatory activity in basal ganglia and cortex plays a pivotal role in the pathophysiology of Parkinson's disease. Recordings of local field potentials from subthalamic nucleus of patients undergoing deep brain stimulation have focused on oscillations occurring at frequencies below 100 Hz in the alpha, beta and gamma range and suggested that, in particular, an increase of beta band oscillations underlies slowing of movement in Parkinson's disease. Recent findings...
Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations Hirschmann, Jan; Butz, Markus; Hartmann, Christian J.; Hoogenboom, Nienke; Özkurt, Tolga Esat; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2016-10-01) BackgroundHigh frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement.
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Citation Formats

J. Hirschmann et al., “Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson’s disease,” NEUROIMAGE, pp. 203–213, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31584.