Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease

Date

2013-03-01

Author

Hirschmann, J.
Özkurt, Tolga Esat
Butz, M.
Homburger, M.
Elben, S.
Hartmann, C. J.
Vesper, J.
Wojtecki, L.
Schnitzler, A.

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Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).

Subject Keywords

Parkinson's disease, Oscillations, MEG, Coherence, STN, Deep brain stimulation

URI

https://hdl.handle.net/11511/31584

Journal

NEUROIMAGE

DOI

https://doi.org/10.1016/j.neuroimage.2012.11.036

Collections

Graduate School of Informatics, Article

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Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations Hirschmann, Jan; Butz, Markus; Hartmann, Christian J.; Hoogenboom, Nienke; Özkurt, Tolga Esat; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2016-10-01) BackgroundHigh frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement.
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Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2011-04-01) Neuronal oscillations are assumed to play a pivotal role in the pathophysiology of Parkinson's disease (PD). Neurons in the subthalamic nucleus (STN) generate oscillations which are coupled to rhythmic population activity both in other basal ganglia nuclei and cortical areas.
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Citation Formats

J. Hirschmann et al., “Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson’s disease,” NEUROIMAGE, pp. 203–213, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31584.