Remarkable cooperative action of two zinc centers in the hydrolysis of plasmid DNA

Aka, FN
Akkaya, Mahinur
Akkaya, EU
A novel binuclear zinc complex has been synthesized. The complex is highly efficient in the hydrolysis of plasmid DNA at pH 7.5. Furthermore, a comparison to a mononuclear complex reveals a high level of cooperativity between the two metal ion centers.


Epoxidation of olefins catalyzed by a molybdenum-Schiff base complex anchored in the pores of SBA-15
Bagherzadeh, Mojtaba; Zare, Maryam; Amini, Mojtaba; Salemnoush, Taghi; Akbayrak, Serdar; Özkar, Saim (Elsevier BV, 2014-12-01)
Novel mesostructured hybrid materials containing a molybdenum Schiff base complex grafted on the internal surface of SBA-15 pores were prepared by introducing MoO2(acac)(2) into a mesoporous silica functionalized with Schiff base ligands. The SBA-15 supports modified by an amine or salicylaldehyde were obtained by co-condensation of tetraethylorthosilicate and the corresponding organosilane in the presence of Pluronic P123 surfactant as a structure directing agent using bis[3-(trimethoxysilyl)propyl]amine o...
Novel neutral phosphinite bridged dinuclear ruthenium(II) arene complexes and their catalytic use in transfer hydrogenation of aromatic ketones: X-ray structure of a new Schiff base, N3,N3 '-di-2-hydroxybenzylidene-[2,2 ']bipyridinyl-3,3 '-diamine
AYDEMİR, MURAT; DURAP, FEYYAZ; BAYSAL, AKIN; MERİÇ, NERMİN; Buldag, Ayseguel; Guemguem, Bahattin; Özkar, Saim; Yildirim, Leyla Tatar (Elsevier BV, 2010-07-01)
A novel Schiff base N3,N3'-di-2-hydroxybenzylidene-[2,2']bipyridinyl-3,3'-diamine, 1 was synthesized from condensation of salicylaldehyde with 3,3'-diamino-2,2'-bipyridine. Reaction of 1 with two equivalents of PPh(2)Cl in the presence of Et(3)N proceeds in toluene to give N3,N3'-di-2-(diphenylphosphino)benzylidene-[2,2']bipyridinyl-3,3'-diamine, 2 in quantitative yield. Ruthenium(II) dimers [Ru(eta(6)-arene)(mu-Cl)]Cl](2) readily react with phosphinite ligand [(Ph(2)PO)(2)-C(24)H(16)N(4)], 2 in toluene at ...
A new strategy for the synthesis of pyridines from N-propargylic beta-enaminothiones
Kelgokmen, Yilmaz; Zora, Metin (Royal Society of Chemistry (RSC), 2019-03-07)
A new method for the synthesis of 2,4,5-trisubstituted pyridines from N-propargylic beta-enaminothiones is reported. beta-Enaminothiones were prepared by thionation of the corresponding beta-enaminones with Lawesson's reagent. When treated with diisopropylamine in DMF at room temperature, N-propargylic beta-enaminothiones yielded 2,4,5-trisubstituted pyridines in moderate to high yields, along with small amounts of 2-methylene-2,3-dihydro-1,4-thiazepines. The reaction was found to be general for a broad ran...
Chemoenzymatic synthesis of both enantiomers of 3-hydroxy-2,3-dihydro-4H-chromen-4-one
Demir, AS; Aybey, A; Sesenoglu, O; Polat, Faruk (Elsevier BV, 2003-06-06)
4-Oxo-3,4-dihydro-2-chromen-3-yl acetate is synthesized using manganese(III)acetate starting from 2,3-dihydro-4H-chromen-4-one. K2CO3 mediated hydrolysis of 4-oxo-3,4-dihdro-2-chromen-3-yl acetate furnished 3-hydroxy-2,3-dihydro-4H-chromen-4-one in high yield. The enantioselective hydrolysis of (+/-)-4-oxo-3,4-dihydro-2-chromen-3-yI acetate in various organic solvent-phosphate buffer (pH7) systems and enantioselective transesterification of (+/-)-3-hydroxy-2,3-dihydro-4H-chromen-4-one in organic solvents wa...
Synthesis of novel norephedrine-based chiral ligands with multiple stereogenic centers and their application in enantioselective addition of diethylzinc to aldehyde and chalcone
Unaleroglu, C; Aydin, AE; Demir, Ayhan Sıtkı (Elsevier BV, 2006-03-06)
Novel norephedrine-based chiral ligands with multiple stereogenic centers were conveniently prepared from norephedrine and N-substituted pyrrole. These novel chiral ligands were used to catalyze the enantioselective addition of diethylzinc to aldehydes and to chalcone in high yields and with good to high enantioselectivities. The absolute configuration of products was found to be affected by the stereogenic centers on the norephedrine part of the novel chiral ligands.
Citation Formats
F. Aka, M. Akkaya, and E. Akkaya, “Remarkable cooperative action of two zinc centers in the hydrolysis of plasmid DNA,” JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, pp. 291–294, 2001, Accessed: 00, 2020. [Online]. Available: