Doku Mühendisliğine Yönelik Biyobozunur Poli ester üretan Sentezlenmesi Karakterizasyonu ve Biyouyumluluğu

Date

2010-04-24

Author

Kızıltay, Aysel
San Roman, Julıo
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin

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Polyurethanes (PUs) are able to degrade into harmless molecules upon implantation and have received a significant level of attention as a biomaterial. PUs based on polycaprolactone (PCL) and amino acid derivatives are examples of these polymers. As a potential biomaterial, their biocompatibility coupled with biodegradability attracted attention in tissue engineering applications. In this study, a biodegradable thermoplastic, poly(ester-urethane) based on L-lysine diisocyanate (LDI) and PCL was synthesized. The resulting polymer was fully characterized with nuclear magnetic resonance spectroscopy (NMR), FTIR-ATR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and mechanical test. The surface properties were studied by goniometer and biocompatibility was evaluated using L929 mouse fibroblast cell line. The FTIR-ATR, and NMR results together provide a proof for the synthesis of the polyurethane polymer. According to thermal analysis results, melting temperature and weight loss were found to be around 48 °C and between 300 °C-450 °C, respectively. Cell culture studies showed that the cells attached and proliferated well and had proper morphology on PU films.

Subject Keywords

Amino acid derivatives, Biodegradable thermoplastics, Polyurethane polymer

URI

https://hdl.handle.net/11511/83094

Conference Name

Biyomedikal Mühendisliği Ulusal Toplantısı, Antalya, Türkiye, (21 - 24 Nisan 20109

Collections

Graduate School of Natural and Applied Sciences, Conference / Seminar

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Citation Formats

A. Kızıltay, J. San Roman, V. N. Hasırcı, and N. Hasırcı, “Doku Mühendisliğine Yönelik Biyobozunur Poli ester üretan Sentezlenmesi Karakterizasyonu ve Biyouyumluluğu,” presented at the Biyomedikal Mühendisliği Ulusal Toplantısı, Antalya, Türkiye, (21 - 24 Nisan 20109, 2010, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/83094.